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World J Orthop. Jul 18, 2014; 5(3): 242-246
Published online Jul 18, 2014. doi: 10.5312/wjo.v5.i3.242
Published online Jul 18, 2014. doi: 10.5312/wjo.v5.i3.242
Osteoporosis and obesity: Role of Wnt pathway in human and murine models
Graziana Colaianni, Giacomina Brunetti, Silvia Colucci, Maria Grano, Department of Basic Medical Science, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Maria Felicia Faienza, Department of Biomedical Sciences and Human Oncology, University of Bari, 70124 Bari, Italy
Author contributions: Colaianni G, Brunetti G, Faienza MF, Colucci S and Grano M wrote the paper.
Correspondence to: Graziana Colaianni, PhD, Department of Basic Medical Science, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy. graziana.colaianni@libero.it
Telephone: +39-080-5478306 Fax: +39-080-5478308
Received: December 29, 2013
Revised: March 4, 2014
Accepted: April 17, 2014
Published online: July 18, 2014
Revised: March 4, 2014
Accepted: April 17, 2014
Published online: July 18, 2014
Core Tip
Core tip: Here we will discuss the role of the key molecules influencing adipocytes and osteoblasts differentiation, which are peroxisome proliferators activated receptor-γ and Wnts, respectively. Besides these proteins, the Wnt inhibitor molecules are also necessary to control the Wnt signalling balance from active to inactive state, in favour of osteogenesis or adipogenesis. It seems remarkably important a deepen analysis of these molecules, not only for their involvement in the regulation of the differentiation processes but also in coordinating the switch toward osteo- or adipo-genesis fate within bone marrow.