Braile A, Toro G, De Cicco A, Cecere AB, Zanchini F, Schiavone Panni A. Hallux rigidus treated with adipose-derived mesenchymal stem cells: A case report. World J Orthop 2021; 12(1): 51-55 [PMID: 33520681 DOI: 10.5312/wjo.v12.i1.51]
Corresponding Author of This Article
Giuseppe Toro, MD, Surgeon, Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio 4, Naples 80138, Italy. giusep.toro@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Jan 18, 2021; 12(1): 51-55 Published online Jan 18, 2021. doi: 10.5312/wjo.v12.i1.51
Hallux rigidus treated with adipose-derived mesenchymal stem cells: A case report
Adriano Braile, Giuseppe Toro, Annalisa De Cicco, Antonio Benedetto Cecere, Fabio Zanchini, Alfredo Schiavone Panni
Adriano Braile, Giuseppe Toro, Annalisa De Cicco, Antonio Benedetto Cecere, Fabio Zanchini, Alfredo Schiavone Panni, Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Naples 80138, Italy
Author contributions: Braile A, Toro G, and Panni AS conceived the study; Cecere AB, and De Cicco AD collected clinical data; Cecere AB, De Cicco AD, and Zanchini F interpreted the obtained data; Braile A and Toro G wrote the article; Panni AS supervised the entire process; all authors revised and approved the final version of the manuscript.
Informed consent statement: As routinely performed, the patient signed a written informed consent in which he authorized the surgical procedure and data collection for research and audit purposes. According to Italian law no formal ethical approval is required for this type of study as it includes routinely performed clinical evaluations.
Conflict-of-interest statement: The authors declare that they had no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Giuseppe Toro, MD, Surgeon, Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio 4, Naples 80138, Italy. giusep.toro@gmail.com
Received: July 27, 2020 Peer-review started: July 27, 2020 First decision: September 21, 2020 Revised: October 5, 2020 Accepted: October 20, 2020 Article in press: October 20, 2020 Published online: January 18, 2021
Core Tip
Core Tip: Recently, the use of intra-articular injections of stem cells has been proposed as a promising treatment in early osteoarthritis. In particular, autologous adipose-derived stem cells (aASCs) have attracted considerable attention, considering the easy access to fat tissue and the absence of adverse events registered. These characteristics make aASCs one of the most promising cell types used in regenerative medicine. Hallux rigidus, is the most frequent degenerative disease of the foot. Patients with hallux rigidus present a history of pain, gait discomfort, articular effusion, and a reduction in range of motion. Different types of treatment are available, both conservative and operative, but both are often ineffective. aASCs might overcome the gap between these two methods of treatment.
