Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis
Blake J Schultz, Malcolm R DeBaun, Michael J Gardner, Department of Orthopedic Surgery, Stanford University, Redwood City, CA 94063, United States
Timothy Sweeney, Melissa Remmel, Uros Midic, Inflammatix, Inc, 863 Mitten Road, Suite 104, Burlingame, CA 94010, United States
Purvesh Khatri, Institute for Immunity, Transplantation and Infections, Center for Biomedical Research, Department of Medicine, Stanford University, Stanford, Redwood City, CA 94305, United States
Author contributions: Sweeney T, Remmel M, Midic U, Khatri P ran the laboratory tests and performed data analysis and interpretation. Schultz BJ, DeBaun MR and Gardner MJ organized and ran the clinical trial. All authors provided critical feedback and helped shape the research, analysis and manuscript. All authors have read and approve of the final submitted manuscript.
Institutional review board statement: All specimens from the patients were obtained after their informed consent and ethical permission was obtained for participation in the study.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Blake J Schultz, MD, Surgeon, Department of Orthopedic Surgery, Stanford University, 450 Broadway Street Pavilion C, 4th Floor, Redwood City, CA 94063, United States. firstname.lastname@example.org
Received: August 14, 2019
Peer-review started: August 14, 2019
First decision: August 30, 2019
Revised: September 19, 2019
Accepted: October 18, 2019
Article in press: October 18, 2019
Published online: December 18, 2019