Published online Sep 18, 2014. doi: 10.5312/wjo.v5.i4.537
Revised: January 24, 2014
Accepted: June 18, 2014
Published online: September 18, 2014
Our understanding of psoriatic arthritis has evolved as new knowledge of the disease has emerged. However, the exact prevalence of psoriatic arthritis is unknown, and its pathogenesis has not been fully elucidated. Genetic, environmental, and immunologic factors have all been implicated in disease development. Early diagnosis and treatment have become primary objectives in clinical rheumatology. Psoriatic arthritis not only causes functional impairment, but also increases mortality risk of patients. The advent of new therapeutic agents capable of arresting the progression of joint damage is expected. However, early psoriatic arthritis assessment remains limited. The objectives of this article are to outline the epidemiology, diagnosis, and treatment of psoriatic arthritis and to suggest a paradigm for identifying early psoriatic arthritis patients.
Core tip: Psoriatic arthritis, usually seronegative for rheumatoid factor, involves the inflammation of synovial tissue, entheses, skin. Clinical manifestation of psoriatic arthritis varies and is under-diagnosed in psoriasis patients. This article presented the epidemiology, diagnosis, and treatment of psoriatic arthritis and to suggest a paradigm for use in standard clinical practice.