Published online Mar 18, 2011. doi: 10.5312/wjo.v2.i3.25
Revised: January 12, 2011
Accepted: January 19, 2011
Published online: March 18, 2011
The relationship between the immune system, estrogen deficiency and bone loss is an intriguing and, as yet, unexplained challenge of the past two decades. Here we summarize the evidence that links immune cells, inflammation, cytokine production and osteoclast formation and activity with particular regard to humans.