Regulation of matrix metalloproteinase-13 in cancer: Signaling pathways and non-coding RNAs in tumor progression and therapeutic targeting

doi:10.5306/wjco.v16.i6.105996

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Jun 24, 2025 (publication date) through Jun 20, 2025

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jun 24, 2025; 16(6): 105996
Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.105996

Regulation of matrix metalloproteinase-13 in cancer: Signaling pathways and non-coding RNAs in tumor progression and therapeutic targeting

Deekshaa Chidambaram, Velan Subashini, Muthuvairaprasath Nanthanalaxmi, Iyyappan Saranya, Nagarajan Selvamurugan

Deekshaa Chidambaram, Velan Subashini, Muthuvairaprasath Nanthanalaxmi, Iyyappan Saranya, Nagarajan Selvamurugan, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, India

Author contributions: Chidambaram D, Subashini V, and Nanthanalaxmi M wrote the manuscript; Saranya I reviewed and edited the manuscript; Selvamurugan N obtained funding for this project and edited and evaluated the text; and all authors thoroughly reviewed and endorsed the final manuscript.

Supported by the Anusandhan National Research Foundation, No. CRG/2023/000212.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Nagarajan Selvamurugan, PhD, Professor, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur 603203, India. selvamun@srmist.edu.in

Received: February 13, 2025
Revised: April 11, 2025
Accepted: May 18, 2025
Published online: June 24, 2025
Processing time: 127 Days and 23.4 Hours

Core Tip

Core Tip: Matrix metalloproteinase-13 (MMP-13) is an important collagenase that plays a critical role in cancer development and metastasis. Several signaling pathways and non-coding RNAs (ncRNAs) regulate MMP-13 expression in various types of cancer. This review explores the mechanisms by which various signaling pathways and different types of ncRNAs, such as long ncRNAs, microRNAs, and circular RNAs, modulate MMP-13 expression in cancer.