Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jun 24, 2025; 16(6): 105691
Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.105691
High hypoxia inducible factor-1α expression is associated with reduced survival in patients with breast cancer: A meta-analysis
Xue-Di Zheng, Huan-Yu Li, Si-Yu Gao, Qi Wang, Jiang-Bo Liu
Xue-Di Zheng, Huan-Yu Li, Si-Yu Gao, Qi Wang, Jiang-Bo Liu, Department of Breast Surgery, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, Henan Province, China
Jiang-Bo Liu, Department of Breast and Thyroid Surgery, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, Henan Province, China
Author contributions: Zheng XD, Li HY, and Liu JB acquisition of data, analysis, and interpretation of data, and drafting the article; Zheng XD, Li HY, Gao SY, Wang Q, and Liu JB interpretation of data, revising the article; Liu JB conception and design of the study, critical revision; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Henan Province Medical Science and Technology Tackling Plan Joint Construction Project, No. LHGJ20220684; and Zhengzhou University Tianjian Advanced Biomedical Laboratory Funding Project, No. BS20240101.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Bo Liu, PhD, Associate Professor, Department of Breast Surgery, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, No. 24 Jinghua Road, Luoyang 471000, Henan Province, China. jiangboliuxing@163.com
Received: February 4, 2025
Revised: April 6, 2025
Accepted: May 13, 2025
Published online: June 24, 2025
Processing time: 136 Days and 23.1 Hours
Core Tip

Core Tip: Hypoxia is a crucial characteristic of tumors that can influence the phenotype of cancer stem cells and contribute to cancer cell invasion and metastasis, thereby significantly impacting the prognosis of cancer patients. This meta-analysis offers a more exhaustive analysis of the relationship between high hypoxia-inducible factor 1α expression and the prognosis of breast cancer patients, providing clinicians with systematic evidence about the role of high hypoxia-inducible factor 1α expression in predicting breast cancer prognosis.