Randomized Controlled Trial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jun 24, 2025; 16(6): 105175
Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.105175
Efficacy and safety of warming Yang and dredging intestines method in metastatic colon cancer maintenance
Yu-Xing Sun, Tong Zhang, Jiang-Yu Bian, Wen-Ting He, Xue-Qian Wang, Chuan-Bo Liu
Yu-Xing Sun, Tong Zhang, Jiang-Yu Bian, Department of Oncology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
Wen-Ting He, Department of Oncology of Chinese Medicine, Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, Beijing 830001, China
Xue-Qian Wang, Department of Oncology, Guang’anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China
Chuan-Bo Liu, Department of Oncology, Oriental Hospital of Beijing TCM University, Beijing 100078, China
Author contributions: Sun YX made substantial contributions to the conception, and revised the article critically for important intellectual content and gave final approval of the version to be published; Zhang T gave substantial contributions to the organization of this trial and revised the article critically; Sun YX and Zhang T made contributions to the design of the study; Bian JY, He WT, Wang XQ, and Liu CB participated in designing and conducting the study and made substantial contribution to the delivery of this study and collected data; and all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82174461; Capacity Enhancement Program of Xiyuan Hospital, China Academy of Traditional Chinese Medicine, No. XYZX0201-22; and Science and Technology Innovation Project of China Academy of Traditional Chinese Medicine, No. CI2021A01811.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Xiyuan Hospital of China Academy of Chinese Medical Sciences, approval No. 2024XLA071-2.
Clinical trial registration statement: This study is registered at International Traditional Medicine Clinical Trial Registry. The registration identification number is ITMCTR2024000229.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tong Zhang, MD, Assistant Professor, Associate Chief Physician, Department of Oncology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. ashtray7654@126.com
Received: January 14, 2025
Revised: April 6, 2025
Accepted: May 15, 2025
Published online: June 24, 2025
Processing time: 157 Days and 18.8 Hours
Core Tip

Core Tip: The current Chinese medicine guideline for metastatic colorectal cancer. lacks a combined Chinese and Western medicine treatment plan for metastatic colorectal cancer maintenance therapy. On the basis of long-term clinical practice and experimental research, this project focuses on the weak link in the maintenance treatment stage, and verifies that the combination of traditional Chinese medicine and Western standard maintenance protocols based on the principle of “warming Yang and dredging intestines” can further improve the clinical efficacy.