Shin T, Okada H. Infertility in men with inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2016; 7(3): 361-369 [PMID: 27602237 DOI: 10.4292/wjgpt.v7.i3.361]
Corresponding Author of This Article
Takeshi Shin, MD, Assistant Professor, Department of Urology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minamikoshigaya, Koshigaya City, Saitama 343-8555, Japan. shintakeshi@nifty.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Pharmacol Ther. Aug 6, 2016; 7(3): 361-369 Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.361
Infertility in men with inflammatory bowel disease
Takeshi Shin, Hiroshi Okada
Takeshi Shin, Hiroshi Okada, Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama 343-8555, Japan
Author contributions: Shin T designed the study, performed the literature review, and wrote the manuscript; Okada H collected data and analyzed them and performed critical revision of the manuscript for important intellectual content; all authors gave final approval of the version of the manuscript to be published.
Conflict-of-interest statement: The authors declare no conflict of interest related to this publication.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Takeshi Shin, MD, Assistant Professor, Department of Urology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minamikoshigaya, Koshigaya City, Saitama 343-8555, Japan. shintakeshi@nifty.com
Telephone: +81-48-9651111 Fax: +81-46-9651111
Received: April 5, 2016 Peer-review started: April 5, 2016 First decision: June 6, 2016 Revised: June 19, 2016 Accepted: July 20, 2016 Article in press: July 22, 2016 Published online: August 6, 2016
Core Tip
Core tip: In men with inflammatory bowel disease (IBD), factors such as surgery, medications, disease activity, and poor nutritional status are thought to contribute to infertility. Surgery with rectal incision is associated with sexual dysfunction (e.g., erectile dysfunction, anejaculation, and retrograde ejaculation). Among medications, sulfasalazine causes reversible qualitative and quantitative semen abnormalities. No other medications seem to affect male fertility significantly. There are limited data on the effects of paternal exposure to IBD medications on pregnancy outcomes, but no significant increase in fetal risk has been noted except for thiopurines. Patients should be appropriately informed of possible effects of paternal drug exposure.
