Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Nov 6, 2015; 6(4): 207-212
Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.207
Age-related differences in celiac disease: Specific characteristics of adult presentation
Santiago Vivas, Luis Vaquero, Laura Rodríguez-Martín, Alberto Caminero
Santiago Vivas, Institute of Biomedicine (IBIOMED), University of León, 24008 León, Spain
Santiago Vivas, Luis Vaquero, Laura Rodríguez-Martín, Department of Gastroenterology, University Hospital of León, 24008 Léon, Spain
Alberto Caminero, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Author contributions: Vaquero L and Rodríguez-Martín L wrote the paper, and prepared the figures and tables; Vivas S and Caminero A designed the outline and coordinated the writing of the paper.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Santiago Vivas, MD, Department of Gastroenterology, University Hospital of León, Altos de Nava s/n, 24008 León, Spain.
Telephone: +34-987-234900-43243 Fax: +34-987-233322
Received: June 2, 2015
Peer-review started: June 3, 2015
First decision: August 4, 2015
Revised: August 24, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: November 6, 2015

Celiac disease may appear both in early childhood and in elderly subjects. Current knowledge of the disease has revealed some differences associated to the age of presentation. Furthermore, monitoring and prognosis of celiac subjects can vary depending on the pediatric or adult stage. The main objective of this review is to provide guidance for the adult diagnostic and follow-up processes, which must be tailored specifically for adults and be different from pediatric patients.

Keywords: Celiac disease, Diagnosis, Complications, Gluten intolerance, Duodenal biopsy

Core tip: Current knowledge of celiac disease (CD) has revealed differences linked to the age of onset. These differences are related to the epidemiology, pathogenicity, clinical signs and prognosis of the disease. Here we present a comprehensive review of CD focusing on the age-specific management of patients. The knowledge of particular aspects linked to either adults or children would improve both the diagnosis and follow-up of this disease. This review can be helpful to the clinician involved in the management of adult and pediatric patients.