Brief Article
Copyright ©2010 Baishideng. All rights reserved.
World J Gastrointest Pharmacol Ther. Aug 6, 2010; 1(4): 81-86
Published online Aug 6, 2010. doi: 10.4292/wjgpt.v1.i4.81
Effect of anesthetics on gastric damage using two models of portal hypertension
Paula RS Câmara, Gisele P Moi, José Geraldo P Ferraz, José Murilo R Zeitune
Paula RS Câmara, Gisele P Moi, UNIVAG, University Center of Várzea Grande, Mato Grosso, Brazil
Gisele P Moi, Biochemistry Laboratory, Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
José Geraldo P Ferraz, Division of Gastroenterology, Faculty of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada
Paula RS Câmara, José Murilo R Zeitune, Division of Gastroenterology, Faculty of Medicine, State University of Campinas, Brazil
Author contributions: Câmara PRS, Ferraz JGP, and Zeitune JMR designed the research; Câmara PRS performed the research; Câmara PRS, Moi GP, Ferraz JGP and Zeitune JMR analyzed the data; Câmara PRS and Moi GP wrote the paper; Ferraz JGP and Zeitune JMR reviewed it; All the authors wrote this paper.
Supported by a Doctoral Grant from the Fundação de Amparo à Pesquisa do Estado do São Paulo (FAPESP), Brazil
Correspondence to: Paula RS Câmara, PhD, UNIVAG, University Center of Várzea Grande, Avenida Dom Orlando Chaves, 2655,Várzea Grande-MT, 78118-000, Brazil.
Telephone: +55-65-36886000 Fax: +55-65-36886015
Received: January 20, 2010
Revised: February 16, 2010
Accepted: February 23, 2010
Published online: August 6, 2010

AIM: To investigate the effect of sodium pentobarbitone (SP) or ketamine/xylazine (KX) anesthetics on acute gastric injury.

METHODS: Portal hypertension was induced by bile duct ligation (BDL) or portal vein stenosis (PVS). Ethanol (EtOH)-induced gastric damage was assessed using ex vivo gastric chamber experiments. Gastric blood flow (GBF) was also measured by laser doppler flowmetry.

RESULTS: EtOH-induced gastric damage was reduced in BDL rats under KX anesthesia in comparison to those under SP anesthesia. GBF dysfunction in fasted BDL rats was partially restored under KX anesthesia. In contrast, in fasted PVS rats, EtOH-induced gastric damage was increased under KX anesthesia while GBF was reduced.

CONCLUSION: The use of KX anesthesia in experimental procedures involving cirrhotic rats (but not those with pure portal hypertension) is preferable to SP anesthesia.

Keywords: Sodium pentobarbitone, Portal hypertension, Cirrhosis, Gastric damage, Ketamine/xylazine