Retrospective Cohort Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Dec 28, 2018; 10(12): 184-189
Published online Dec 28, 2018. doi: 10.4329/wjr.v10.i12.184
Management of computed tomography scan detected hemothorax in blunt chest trauma: What computed tomography scan measurements say?
Mahdi Malekpour, Kenneth Widom, James Dove, Joseph Blansfield, Mohsen Shabahang, Denise Torres, Jeffrey L Wild
Mahdi Malekpour, Kenneth Widom, James Dove, Joseph Blansfield, Mohsen Shabahang, Denise Torres, Jeffrey L Wild, Department of Surgery, Section of Trauma and Acute Care Surgery, Geisinger Medical Center, Danville, PA 17822, United States
ORCID number: Mahdi Malekpour (0000-0002-7337-3479); Kenneth Widom (0000-0003-1806-8524); James Dove (0000-0002-5673-5394); Joseph Blansfield (0000-0002-1652-3274); Mohsen Shabahang (0000-0002-7227-3636); Denise Torres (0000-0003-0004-3257); Jeffrey L Wild (0000-0002-1999-4311).
Author contributions: Malekpour M, Shabahang M and Wild JL designed of the Study; Malekpour M, Dove J and Blansfield J collected data; Widom K and Torres D analyzed the data; Malekpour M, Widom K, Dove J, Blansfield J, Shabahang M, Torres D and Wild JL prepared the draft and finalized the manuscript.
Institutional review board statement: Approved by Geisinger Institutional Review Board under the IRB # 2014-0533.
Informed consent statement: Due to anonymity of this research, patients were not required to provide a separate consent form as being approved by IRB of Geiringer Medical Center.
Conflict-of-interest statement: Authors included in this study have no conflict-of-interest and nothing to disclose.
Data sharing statement: No patient identification data is included in this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author to: Jeffrey L Wild, MD, Doctor, Staff Physician, Surgeon, Department of Surgery, Section of Trauma and Acute Care Surgery, Geisinger Medical Center, 100 North Academy Avenue, MC 21-69, Danville, PA 17822, United States. jlwild@geisinger.edu
Telephone: +1-570-2716361 Fax: +1-570-2717165
Received: June 5, 2018
Peer-review started: June 5, 2018
First decision: July 27, 2018
Revised: September 17, 2018
Accepted: November 24, 2018
Article in press: November 24, 2018
Published online: December 28, 2018

Abstract
AIM

To investigate the hemothorax size for which tube thoracostomy is necessary.

METHODS

Over a 5-year period, we included all patients who were admitted with blunt chest trauma to our level 1 trauma center. Focus was placed on identifying the hemothorax size requiring tube thoracostomy.

RESULTS

A total number of 274 hemothoraces were studied. All patients with hemothoraces measuring above 3 cm received a chest tube. The 50% predicted probability of tube thoracostomy was 2 cm. Pneumothorax was associated with odds of receiving tube thoracostomy for hemothoraces below 2 cm (Odds Ratio: 4.967, 95%CI: 2.225-11.097, P < 0.0001).

CONCLUSION

All patients with a hemothorax size greater than 3% underwent tube thoracostomy. Prospective studies are warranted to elucidate the clinical outcome of patients with smaller hemothoraces.

Key Words: Chest trauma, Blunt, Hemothorax, Chest tube, Occult, Computed tomography scan

Core tip: There is no clear recommendation for tube thoracostomy in hemothorax management based on computed tomography scan measurements. In this study, we found that any hemothoraces above the cut-off size of 3 cm should be drained using tube thoracostomy. Smaller hemothoraces may warrant drainage based on other findings such as presence of pneumothorax.



INTRODUCTION

Blunt chest trauma is commonly encountered in the emergency department as an individual presentation or part of the clinical scenario of a trauma patient[1]. According to the 2012 National Trauma Data Bank (NTDB) Research Data Set, 738396 patients with available Abbreviated Injury Scale were admitted nationwide. Patients with chest trauma constituted 87387 (11.8%) of the registered patients among which, 73809 (84.5% of chest trauma patients) had blunt chest trauma and 12200 (16.5% of blunt chest trauma patients) had hemothorax (Committee on Trauma, American College of Surgeons. NTDB 2012. Chicago, IL).

Although hemothorax is managed by tube thoracostomy in hemodynamically unstable and critical patients after initial chest/pelvic x-ray and focused assessment with sonography in trauma (FAST), virtually all stable blunt trauma patients undergo chest computed tomography (CT) scan as part of their trauma workup[2]. This is partially due to higher sensitivity of chest CT imaging in detecting pneumothorax, hemothorax and pulmonary contusions along with suboptimal imaging preparation and positioning for supine chest radiography in the acute setting[3]. Tube thoracostomy is an invasive procedure which can lead to immediate procedural injuries, infections, and pain, which can contribute to respiratory failure in patients with chest wall injury. Patients with hemothoraces managed without chest tube can lead to infections and trapped lung. Therefore, it is clinically important to know which patients should receive a chest tube.

At the advent of helical CT scanning, chest CT scan was reserved for cases where chest radiography had uncertain and equivocal results. Hence, up to 30% of blunt trauma patients had their hemothoraces identified on chest CT images, which were not readily identifiable on plain chest X-rays, a.k.a. occult hemothorax[4-6]. Thanks to fairly universal application of chest CT in assessment of blunt chest trauma patients, “occult hemothorax” is not practically occult anymore. In fact, the previously published research papers on occult hemothorax have included hemothoraces that are undoubtedly within the identification range of chest radiography[6,7]. In addition, these studies have included extrapolations from plain radiography studies as their cutoff value, primarily due to the absence of existing studies focusing on chest CT measurements[6-9].

In this study, we investigated the association between the measured size of hemothoraces on chest CT images and the likelihood of tube thoracostomy in an attempt to identify a CT scan-based cutoff value of chest tube placement in blunt chest trauma patients.

MATERIALS AND METHODS

Following the approval of the Institutional Review Board of Geisinger Medical Center, we retrospectively studied all patients with the diagnosis of hemothorax and blunt chest trauma that were admitted to our level I trauma center from the beginning of September 2009 to the end of August 2014. Excluded patients were those who were admitted after 24 h from the traumatic accident, patients who were admitted with a chest tube in place, those with chest tube placement before CT scan imaging, patients with chronic hemothorax and those with known pleural diseases. The decision to place a chest tube was based on the clinical judgement of the trauma surgeon for each individual case.

We extracted demographic and clinical data including age, sex, Injury Severity Score (ISS), mechanism of injury, Glasgow Coma Score (GCS), pneumothorax, number of rib fractures, pulmonary contusion and aortic injury. These variables were used in multivariate analysis. Hemothorax was measured as the size (centimeters) of the deepest lamellar fluid stripe in the dependent pleural gutter on axial CT scan images (Figure 1).

Figure 1
Figure 1 Representative computed tomography scan images of patients with hemothorax. Left: Abdominal window computed tomography (CT) scan showing a 2 cm right-side hemothorax in one patient; Right: Lung window CT scan showing a 6 cm right-side hemothorax in another patient.

Continuous variables were expressed as means ± SD. Non-parametric continuous data were expressed as median with inter-quartile range. Categorical data were expressed as frequencies (%). Logistic regression was used to analyze the predicted probability for tube thoracostomy. Logistic regression with stepwise selection was used to identify variables that increased the chance of tube thoracostomy. SAS 9.4 (SAS Institute, Cary NC) was used for statistical analyses and P < 0.05 was considered significant.

RESULTS

Over the 5-year study period, 271 patients were admitted with the diagnosis of hemothorax and blunt chest trauma. Forty-three patients were excluded and the analysis was performed on the remaining 228 patients. A total number 274 hemothoraces were included from 150 males and 78 females. Table 1 summarized the demographic data and the clinical findings of our patients. The mechanism of injury was predominantly fall (41%) and motor vehicle crash (38%). Patients had a mean ISS of 20 ± 11. Most patients (86%) had a mild GCS (13-15). The median number of rib fractures was 5 (3, 8) and pneumothorax was identified in 128 (56%) patients.

Table 1 Demographic data.
Variablen (%)
Age (yr), (mean ± SD)60.8 ± 19.5
Gender
Female78 (34)
Male150 (66)
Mechanism of injury
Fall93 (41)
MCC25 (11)
MVC86 (38)
Other21 (9)
Pedestrian struck3 (1)
ISS (mean ± SD)20 ± 11
GCS
Severe25 (11)
Moderate6 (3)
Mild197 (86)
Associated pneumothorax128 (56)
Number of rib fractures, median (IQR)5 (3, 8)
Pulmonary contusion112 (49)
Aortic injuries7 (3)
Size (cm) , median (IQR)1.4 (0.9, 2.4)

The median size of hemothorax was 1.4 cm (0.9, 2.4). As shown in Figure 2, using logistic regression, we plotted the chest tube insertion versus the measured size in the predicted probability graph. All patients with hemothoraces measuring above 3 cm underwent tube thoracostomy. We found that the probability of receiving a chest tube was more than 50% when the hemothorax measured more than 2.05 cm.

Figure 2
Figure 2 Predicted probability for tube thoracostomy. The x-axis is the size of hemothorax and the y-axis is the probability of chest tube placement, which is either zero (no chest tubes) or one (chest tube placed). Each black dot represents a patient with a corresponding hemothorax size.

Logistic regression with stepwise selection was used to identify variables associated with odds of receiving a chest tube for hemothoraces < 2 cm. As table 2 summarizes, ISS and associated pneumothorax were associated with significantly higher odds of tube thoracostomy (P = 0.004 and P < 0.0001, respectively). In the 2-3 cm hemothorax range, between 14 patients who underwent tube thoracostomy, pneumothorax was not identified in two (14%). In the same hemothorax range, 15 patients did not receive a chest tube with pneumothorax absent in six (40%). In the remaining 9 patients (60%), pneumothoraces were radiographically identified as compromising less than 5% of the volume of the ipsilateral hemothorax.

DISCUSSION

We have reported the first study investigating the likelihood of tube thoracostomy based on the measurement of hemothoraces in chest CT scans of blunt chest trauma patients. We found that tube thoracostomy was performed in all patients with hemothoraces measuring more than 3 cm. We also found that the chance of tube thoracostomy was above 50% in patients with hemothoraces measuring above 2 cm; with pneumothorax significantly influencing the decision making. Although a few studies have investigated management of occult hemothorax and included the size in their analyses[6,7,10], they are primarily limited in founding their criteria on extrapolations of chest radiography measurements[8,9], which would highlight why our study was necessary.

The first study directly investigating chest tube placement in management of occult hemothorax was published in 2005 by Bilello et al[6] As the investigators stated, measurements and the 1.5 cm cutoff was set by extrapolation of pleural fluid measurements in chest radiography. Nearly half of the hemothoraces in this study were classified as moderate/large, which by definition, should have been identified in chest radiography and not be included in the study. The following year, another study was published by Stafford et al[10] on the incidence and management of occult hemothorax. In this study, the mean measurement of hemothorax in patients receiving chest tubes was close to 2 cm. More recently, the prospective study by Mahmood et al[7] in 2011 also reported 18% of the patients (the comparison group) to have measurements above 1.5 cm.

This discrepancy might be stemming from difficulty of extrapolation of chest radiography measurements into chest CT scan measurements. Some of the earlier chest X-ray measurements were based on lateral decubitus measurements rather than decubitus images[11]. In addition, chest X-ray fluid measurements propose a range of volumes rather than an exact number[8]. The need to have CT scan-based recommendations is also stemming from clinicians’ inclination towards chest CT scan rather than relying on chest X-ray images. This inclination is scientifically supported by a very recent study showing that up to 71% of patients with blunt chest injury have some or all injuries identified only on chest CT scans[12]. This shows why there was a need for a study based on CT scan measurements alone.

Based on aforementioned literature, the term “occult hemothorax” might not be a clinically applicable name as almost all patients with blunt chest trauma would undergo chest CT scan, which is capable of picking smallest effusions. Hence, the term “small hemothorax” would better delineate the clinical picture as “overt hemothorax” (i.e., large hemothoraces that are identified readily with FAST or chest X-ray) is the only practically true clinical entity that would undergo tube thoracostomy before chest CT imaging.

Our studied population is rather comparable to previously studied patients. In the Bilello et al[6] study, 78 patients with an average ISS close to 25 were included. Less than 40% of patients required tube thoracostomy[6]. The study of Stafford et al[10] included 88 patients with an average ISS of 20. Chest tubes were required in 48% of patients[10]. Lastly, the prospective study by Mahmood et al[7] included 81 patients with an average ISS of 18. Tube thoracostomy was required in only 17% of patients, which is probably reflecting the better job of a prospective study to include patients with smaller hemothoraces. Our study is thus far the largest study that includes 274 hemothoraces from 228 patients.

This study was limited by the operator-based measurements of hemothoraces. Availability or design of a computerized program to measure hemothorax would potentially eliminate this bias. Another limitation was stemming from the radiographic appearance of hemothorax, which does not always form a complete crescentic shape in trauma. Therefore, it is not always easy to define the deepest lamellar fluid stripe. A program that can measure the volume of the hemothorax rather than one single measurement of the thickness would overcome this limitation. Volumetric measurements have been used in other areas of medicine and would be a reachable goal in hemothorax studies[13,14]. Finally, our study was limited by the absence of tube thoracostomy criteria in small hemothoraces. Although the study was performed in a level I trauma center with well-trained trauma surgeons, the final decision of tube thoracostomy was made by the clinical judgement of the trauma surgeon. By expanding the study period over 5 years and including all patients, we tried to partially overcome this limitation. A prospective study including multiple centers with defined criteria for tube thoracostomy would overcome several of the limitations and would be a promising next-step to our current study.

In conclusion, based on chest CT scan measurements, patients with hemothoraces measuring above 3 cm required tube thoracostomy. Hemothoraces greater than 2 cm had more than 50% chance of receiving a chest tube. Further prospective studies are required to validate the cutoff and to investigate associations with outcomes.

ARTICLE HIGHLIGHTS
Research background

No definite recommendation exists on the size of hemothoraces that require drainage using tube thoracostomy.

Research motivation

Hemothoraces are prevalent findings in trauma patients, yet, no standard-of-care exists that identifies need for chest tube placement based on the size of the hemothorax.

Research objectives

Identifying the cut-off size for a hemothorax based on computed tomography findings that would warrant placement of a chest tube.

Research methods

Retrospective study of a trauma center database

Research results

Patients with hemothorax size over 3 cm received chest tube. In patients with smaller hemothoraces, presence of other findings such as pneumothorax warrants placement of chest tube.

Research conclusions

Tube thoracostomy should be performed in any trauma patient with a hemothorax size of greater than 3 cm.

Research perspectives

Findings are immediately applicable to the practice of trauma surgery at our center. It would also be beneficial for other subspecialties including emergency medicine, radiology and pulmonary medicine.

Footnotes

Manuscript source: Invited manuscript

Specialty type: Radiology, nuclear medicine and medical imaging

Country of origin: United States

Peer-review report classification

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P- Reviewer: Akbulut S, Sergi CM, Kai K S- Editor: Wang JL L- Editor: A E- Editor: Bian YN

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