Published online Aug 28, 2015. doi: 10.4329/wjr.v7.i8.212
Peer-review started: May 3, 2015
First decision: June 18, 2015
Revised: July 7, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: August 28, 2015
AIM: To develop a new type of calibrated, biodegradable, and imaging detectable microsphere and evaluated its embolization safety and efficacy on pig’s liver and spleen.
METHODS: Six kinds of pharmaceutical excipient were combined and atomized to form our microsphere. Twenty-four male Lanyu pigs weighing 25-30 kg were used. The arteries of spleen and liver were embolized with Gelfoam, Embosphere, or our microsphere. The serum biochemical tests, computed tomography (CT), liver perfusion scan, and tissue microscopy examination were done to evaluate the safety and efficacy of embolization.
RESULTS: Radiopaque microspheres with a size ranging from 300 to 400 μm were produced. Embolization of hepatic and splenic artery of pigs with our microsphere significantly reduced the blood flow of liver and resulted in splenic infarction. The follow-up CT imaging and the microscopic examination showed intraarterial degradation of Gelfoam and microsphere. The blood tests demonstrated insignificant changes with regards to liver and renal functions.
CONCLUSION: Our microspheres, with the unique characteristics, can be used for transcatheter arterial embolization with effects equivalent to or better than Gelfoam and Embosphere in pigs.
Core tip: Transcatheter arterial embolization (TAE) is the treatment of choice for intermediate stage hepatocellular carcinoma. Various embolization materials have been designed for this purpose. By using atomization technique and a mixture of pharmaceutical excipient, we developed a new type of calibrated, biodegradable, and imaging detectable microsphere. We proved that our microspheres, with the unique characteristics, can be used for TAE with effects equivalent to or better than Gelfoam and Embosphere in pigs.