Brief Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Radiol. Aug 28, 2011; 3(8): 205-209
Published online Aug 28, 2011. doi: 10.4329/wjr.v3.i8.205
Value of acoustic radiation force impulse elastography for the assessment of ascites syndrome
Simona Bota, Ioan Sporea, Roxana Şirli, Alina Popescu, Mirela Dănilă, Mădălina Şendroiu
Simona Bota, Ioan Sporea, Roxana Şirli, Alina Popescu, Mirela Dănilă, Mădălina Şendroiu, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy, 300742, Timişoara, Romania
Author contributions: Bota S designed and wrote the paper; Sporea I supervised the study; Bota S, Sporea I, Şirli R, Popescu A, Dănilă M and Şendroiu M performed the research; Bota S analyzed the data; Şirli R revised the manuscript.
Correspondence to: Simona Bota, PhD, Department of Gastroenterology, University of Medicine and Pharmacy, 2, Intrarea Martir Angela Sava str., 300742, Timişoara, Romania. bota_simona1982@yahoo.com
Telephone: +40-721-656147 Fax: +40-256-488003
Received: June 1, 2011
Revised: July 12, 2011
Accepted: July 19, 2011
Published online: August 28, 2011
Abstract

AIM: To assess the feasibility of performing acoustic radiation force impulse (ARFI) elastography in patients with ascites and its predictive value for the cirrhotic or non-cirrhotic etiology of ascites. METHODS: Our study included 153 patients with ascites, mean age 58.8 ± 13.1 years. One hundred and fifteen (75.2%) patients had ascites in the context of cirrhosis, 29 (18.9%) had non-cirrhotic ascites (diagnosed by clinical, ultrasound, endoscopic and/or laparoscopic criteria) and in 9 (5.9%) cases we could not establish the etiology of ascites. We performed 10 ARFI measurements and the median value was calculated and expressed in meters/second (m/s). Among the 29 patients with non-cirrhotic ascites were included: 20 laparoscopically demonstrated peritoneal carcinomatosis with histological confirmation, 7 acute pancreatitis with ascites which later resolved, and one case each of lymphatic ascites and ascites in the context of a liver abscess. In 11 of the 20 patients with peritoneal carcinomatosis, the liver structure was homogenous in the ultrasound examination and in 9 patients the ultrasound exam revealed liver metastases. RESULTS: We could not obtain valid ARFI measurements in 5 patients (3.2%). The mean liver stiffness measurements by means of ARFI were statistically significantly higher in patients with cirrhotic ascites than in those with non-cirrhotic ascites: 3.04 ± 0.70 vs 1.45 ± 0.59 m/s (P < 0.001). For a cut-off value of 1.8 m/s for predicting cirrhosis (and ascites in the context of cirrhosis), as obtained in a previous study, ARFI had 98.1% sensitivity, 86.2% specificity, 96.4% positive predictive value, 92.5% negative predictive value and 95.6% accuracy for predicting cirrhotic ascites. For a cut-off value of 1.9 m/s the accuracy was 94.9% and for a 2 m/s cut-off value it was 92.8%. CONCLUSION: ARFI elastography is feasible in most patients with ascites and has a very good predictive value for the cirrhotic or non-cirrhotic etiology of ascites.

Keywords: Ascites; Liver stiffness; Liver cirrhosis; Acoustic radiation force impulse; Elastography