Liu JM, Li Z, Qi LH, Chu BL, Deng ZX, Tang FY. Imaging features of appendiceal signet ring cell carcinoma with uterine implantation: A case report. World J Radiol 2025; 17(8): 110868 [DOI: 10.4329/wjr.v17.i8.110868]
Corresponding Author of This Article
Feng-Yun Tang, Deputy Director, Department of General Practice, Baiyang Community Health Service Center, Baiyang Street, Qiantang District, Hangzhou 310000, Zhejiang Province, China. bbyxy804@126.com
Research Domain of This Article
Imaging Science & Photographic Technology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jia-Mi Liu, Zhi Li, Ling-Hong Qi, Department of Radiology, Huzhou Maternity & Child Health Care Hospital, Huzhou 313000, Zhejiang Province, China
Bo-Liang Chu, Department of Gynaecology, Huzhou Maternity & Child Health Care Hospital, Huzhou 313002, Zhejiang Province, China
Zai-Xing Deng, Department of Pathology, Huzhou Maternity & Child Health Care Hospital, Huzhou 313000, Zhejiang Province, China
Feng-Yun Tang, Department of General Practice, Baiyang Community Health Service Center, Hangzhou 310000, Zhejiang Province, China
Co-first authors: Jia-Mi Liu and Zhi Li.
Author contributions: Liu JM and Li Z have the equal contribution to the manuscript; Liu JM and Li Z contributed to drafting of manuscript; Qi LH and Liu JM contributed to assessment of imaging examination; Chu BL and Deng ZX contributed to the acquisition of data; Tang FY was responsible for conceptualization and design of the study, guiding the writing of the paper and quality control; all the authors solely contributed to this paper.
Informed consent statement: Written informed consent was obtained from the patient to publish this paper.
Conflict-of-interest statement: We have no financial relationships to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng-Yun Tang, Deputy Director, Department of General Practice, Baiyang Community Health Service Center, Baiyang Street, Qiantang District, Hangzhou 310000, Zhejiang Province, China. bbyxy804@126.com
Received: June 18, 2025 Revised: July 16, 2025 Accepted: August 8, 2025 Published online: August 28, 2025 Processing time: 72 Days and 6.4 Hours
Abstract
BACKGROUND
Signet ring cell carcinoma originating from the appendix is extremely rare, and the lack of specific clinical symptoms and imaging features makes preoperative diagnosis particularly challenging.
CASE SUMMARY
We report a case of a 49-year-old woman who presented with irregular vaginal bleeding lasting more than five months. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed an enlarged appendix with a thickened wall and progressive enhancement after contrast administration. The uterine myometrium and cervix were markedly thickened, with heterogeneous density and signal intensity, along with progressive enhancement. The uterine serosal surface remained intact. Preoperative MRI suggested diffuse uterine adenomyosis; however, postoperative histopathology confirmed Signet ring cell carcinoma originating from the appendix with implantation involving the entire uterus.
CONCLUSION
Imaging showed appendiceal wall thickening and marked thickening of the uterine myometrium, with lesions demonstrating progressive enhancement after contrast administration. These findings should raise suspicion for the implantation of Signet ring cell carcinoma originating from the appendix and involving the uterus. Signet ring cell carcinoma originating from the appendix is relatively rare, and its imaging features are seldom reported, making preoperative diagnosis extremely challenging. This study retrospectively analyzes a case of Signet ring cell carcinoma originating from the appendix with implantation involving the entire uterus. The imaging characteristics of the appendix and the uterus were evaluated using CT and MRI to enhance awareness of this disease.
Core Tip: Signet ring cell carcinoma originating from the appendix is relatively rare, and its imaging features are seldom reported, making preoperative diagnosis extremely challenging. This study retrospectively analyzes a case of Signet ring cell carcinoma originating from the appendix and implantation to the entire uterus. The imaging characteristics of both the appendix and the uterus were analyzed using computed tomography and magnetic resonance imaging, with the aim of enhancing awareness of this disease.
