Mood alteration and heart rate variability in patients with cancer on treatment

doi:10.4330/wjc.v17.i6.107114

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Jun 26, 2025 (publication date) through Jun 20, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Jun 26, 2025; 17(6): 107114
Published online Jun 26, 2025. doi: 10.4330/wjc.v17.i6.107114

Mood alteration and heart rate variability in patients with cancer on treatment

Yun-Chen Chang, Wei-Nung Liu, Felicia Lin, Gen-Min Lin

Yun-Chen Chang, School of Nursing and Graduate Institute of Nursing, China Medical University, Taichung 406, Taiwan

Yun-Chen Chang, Department of Nursing, China Medical University Hospital, Taichung 404, Taiwan

Wei-Nung Liu, Gen-Min Lin, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan

Felicia Lin, Community Care, Minnesota Oncology, Minneapolis, MN 55404, United States

Gen-Min Lin, Department of Internal Medicine, Hualien Armed Forces General Hospital, Hualien City 970, Taiwan

Author contributions: Chang YC wrote the article; Liu WN, Lin F and Lin GM made critical revisions related to important content of the manuscript; and all authors provided approval of the final version of the article to be published.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Gen-Min Lin, Director, FACC, FAHA, FESC, Department of Medicine, Hualien Armed Forces General Hospital, No. 100 Jinfeng Street, Hualien City 970, Taiwan. farmer507@yahoo.com.tw

Received: March 16, 2025
Revised: April 11, 2025
Accepted: April 28, 2025
Published online: June 26, 2025
Processing time: 96 Days and 21.5 Hours

Core Tip

Core Tip: We discussed that the reduced heart rate variability may be associated with cancer treatments, e.g., operation, chemotherapy and pain control and psychological response such as depression and anxiety related to the affected cancer. A management such as medicine to mood disturbances related to cancer has been shown a benefit to improve heart rate variability in cancer patients.