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World J Biol Chem. Sep 5, 2025; 16(3): 108045
Published online Sep 5, 2025. doi: 10.4331/wjbc.v16.i3.108045
CD47/SIRPα pathways: Functional diversity and molecular mechanisms
Nitin Bhardwaj, Harish Chandra, Ashutosh Singh, Ram Babu
Nitin Bhardwaj, Department of Zoology and Environmental Sciences, Gurukula Kangri (Deemed to be University), Haridwar 249404, India
Harish Chandra, Department of Botany and Microbiology, Gurukula Kangri (Deemed to be University), Haridwar 249404, India
Ashutosh Singh, Department of Biochemistry, University of Lucknow, Lucknow 226007, India
Ram Babu, Department of Botany, Kirori Mal College, New Delhi, India 110067, India
Author contributions: Material preparation, data collection and analysis were performed by Bhardwaj N, Chandra H, Singh A and Babu R; the first draft of the manuscript was written by Bhardwaj N and all authors commented on previous versions of the manuscript; all authors read and approved the final manuscript.
Supported by Indian Council for Medical Research, No. 56/2/Hae/BMS; and University Grant Commission Start-Up Grant, No. 30-496/2019.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nitin Bhardwaj, PhD, Assistant Professor, Department of Zoology and Environmental Sciences, Gurukula Kangri (Deemed to be University), Jagjeetpur, Haridwar 249404, India. nitindna2001@gmail.com
Received: April 9, 2025
Revised: May 13, 2025
Accepted: August 5, 2025
Published online: September 5, 2025
Processing time: 150 Days and 18.8 Hours
Core Tip

Core Tip: In the current review, we discussed multifunctional roles (apoptosis, phagocytosis, metabolism, activation, hematopoietic stem cell migration, and malignancies) and molecular mechanisms of CD47/signal regulatory protein α receptors in various cells.