Bhardwaj N, Chandra H, Singh A, Babu R. CD47/SIRPα pathways: Functional diversity and molecular mechanisms. World J Biol Chem 2025; 16(3): 108045 [DOI: 10.4331/wjbc.v16.i3.108045]
Corresponding Author of This Article
Nitin Bhardwaj, PhD, Assistant Professor, Department of Zoology and Environmental Sciences, Gurukula Kangri (Deemed to be University), Jagjeetpur, Haridwar 249404, India. nitindna2001@gmail.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nitin Bhardwaj, Department of Zoology and Environmental Sciences, Gurukula Kangri (Deemed to be University), Haridwar 249404, India
Harish Chandra, Department of Botany and Microbiology, Gurukula Kangri (Deemed to be University), Haridwar 249404, India
Ashutosh Singh, Department of Biochemistry, University of Lucknow, Lucknow 226007, India
Ram Babu, Department of Botany, Kirori Mal College, New Delhi, India 110067, India
Author contributions: Material preparation, data collection and analysis were performed by Bhardwaj N, Chandra H, Singh A and Babu R; the first draft of the manuscript was written by Bhardwaj N and all authors commented on previous versions of the manuscript; all authors read and approved the final manuscript.
Supported by Indian Council for Medical Research, No. 56/2/Hae/BMS; and University Grant Commission Start-Up Grant, No. 30-496/2019.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nitin Bhardwaj, PhD, Assistant Professor, Department of Zoology and Environmental Sciences, Gurukula Kangri (Deemed to be University), Jagjeetpur, Haridwar 249404, India. nitindna2001@gmail.com
Received: April 9, 2025 Revised: May 13, 2025 Accepted: August 5, 2025 Published online: September 5, 2025 Processing time: 150 Days and 18.8 Hours
Abstract
Cellular communication is required for the normal function and maintenance of homeostasis. The extracellular communications are mediated by cell surface receptors, which transmit signals for various cell functions. Cell defense also relies on distinguishing between self and non-self. The integrins belong to the transmembrane receptors family and serve a crucial function in cell-extracellular adhesion and cell–cell signaling. The cell surface integrin-associated protein, or CD47, is an important integrin regulator and performs an array of functions. The CD47 interacts with the signal regulatory protein α (SIRPα) and regulates adhesion, apoptosis, phagocytosis, proliferation, metabolism, activation, hematopoietic stem cell migration, and malignancies. The CD47 expression is increased in tumor cells to escape immune response. The anti-CD47 antibodies have shown promising therapeutic strategies in various clinical trials in the treatment of hematologic and solid tumors. In the current review, we discussed multifunctional roles, molecular mechanisms, and therapeutic strategies of tumors by utilizing CD47/SIRPα interactions.
Core Tip: In the current review, we discussed multifunctional roles (apoptosis, phagocytosis, metabolism, activation, hematopoietic stem cell migration, and malignancies) and molecular mechanisms of CD47/signal regulatory protein α receptors in various cells.
