Clinical Trials Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2017; 8(5): 202-212
Published online May 15, 2017. doi: 10.4239/wjd.v8.i5.202
Association between dairy intake, lipids and vascular structure and function in diabetes
Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Jacquelyn M Weir, Peter J Meikle, Peter M Clifton
Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Peter M Clifton, School of Pharmacy and Medical Sciences and Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5000, Australia
Jacquelyn M Weir, Peter J Meikle, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
Author contributions: Petersen KS saw the volunteers, measured the physiological and dietary variables, analysed the data and wrote the first draft; Clifton PM and Keogh JB designed the study, analysed the data and drafted the manuscript; Lister N measured the physiological and dietary variables; Weir JM and Meikle PJ performed the lipidomics; all authors read and approved the final manuscript.
Supported by the Heart Foundation and the Government of South Australia, No. CR 12A 6750 to Keogh JB; NHMRC Principal Research Fellowship, No. APP1125691 to Clifton PM; NHMRC Senior Research Fellowship, No. APP1042095 to Meikle PJ; an Australian Postgraduate Award, No. 138093 to Petersen KS; and a University of South Australia Postgraduate Award, No. 128123 to Lister N.
Institutional review board statement: Ethics approval was obtained from the University of South Australian Human Research Ethics Committee.
Clinical trial registration statement: The trial was registered with the Australian New Zealand Clinical Trials Registry (www.anzctr.org.au/) (ACTRN12613000251729) on 4/09/2014.
Informed consent statement: All the participants provided written informed consent prior to study enrolment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: Dataset available from the corresponding author at Jennifer.keogh@unisa.edu.au. Consent for data sharing was not obtained but the data is anonymised and risk of identification is very low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Jennifer B Keogh, School of Pharmacy and Medical Sciences and Sansom Institute for Health Research, University of South Australia, GPO Box 2471 Adelaide, SA 5000, Australia. jennifer.keogh@unisa.edu.au
Telephone: +61-8-83022579 Fax: +61-8-83022389
Received: October 25, 2016
Peer-review started: October 28, 2016
First decision: December 1, 2016
Revised: December 15, 2016
Accepted: March 12, 2017
Article in press: March 13, 2017
Published online: May 15, 2017
Core Tip

Core tip: We have examined the relationship between changes in dairy intake, lipid species and vascular function. Although it was expected that an increase in dairy intake would lower blood pressure and be associated with improvements in vascular structure we found that increases in lipid species associated with dairy (LPC 14:0, LPC 15:0, LPC 16:1, CE 14:0) were associated with adverse changes in these parameters. Dairy does not appear to be beneficial in people with diabetes.