Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.109
Peer-review started: July 24, 2014
First decision: August 15, 2014
Revised: August 17, 2014
Accepted: November 27, 2014
Article in press: December 1, 2014
Published online: February 15, 2015
Core tip: Recent studies have revealed that a deficit of β-cell functional mass is an essential component of the pathophysiology of type 2 diabetes (T2DM). β-cell dysfunction is present at the diagnosis of T2DM and progressively worsens with disease duration. β-cell dysfunction is associated with worsening of glycemic control and treatment failure; thus, it is important to preserve or recover β-cell functional mass in the management of T2DM. This review summarizes the current knowledge on β-cell functional mass in T2DM and discusses the treatment strategy for T2DM.