Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2025; 16(6): 103520
Published online Jun 15, 2025. doi: 10.4239/wjd.v16.i6.103520
Efficacy and safety of negative pressure wound therapy for the treatment of diabetic foot ulcers: A meta-analysis
Yun-Xiang Deng, Xiao-Chuan Wang, Zhen-Yu Xia, Meng-Ya Wan, Du-Yin Jiang
Yun-Xiang Deng, Zhen-Yu Xia, Meng-Ya Wan, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Xiao-Chuan Wang, Department of Plastic Surgery & Burns, The Second Hospital of Shandong University, Jinan 250033, Shandong Province, China
Du-Yin Jiang, Emergency Medicine Center, The Second Hospital of Shandong University, Jinan 250033, Shandong Province, China
Author contributions: Deng YX, Wang XC and Xia ZY conceptualized the study; Deng YX and Wan MY curated the data; Deng YX, Wang XC, and Wan MY conducted the formal analysis; Deng YX and Xia ZY developed the methodology; Deng YX and Wang XC provided resources; Deng YX and Xia ZY were responsible for software implementation; Deng YX drafted the original manuscript, and Jiang DY performed the review and editing.
Supported by the National Natural Science Foundation of China, No. 82202454 and No. 81873934; the Wang Zhengguo Trauma Medicine Fund (Growth Factor Revival Plan) No. SZYZ-TR-09; the Shandong Provincial Natural Science Foundation Youth Fund, No. ZR2020QH168; and the Jinan Science and Technology Plan Project, No. 202225065.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Du-Yin Jiang, MD, Emergency Medicine Center, The Second Hospital of Shandong University, No. 247 Beiyuan Street, Jinan 250033, Shandong Province, China. duyinjiang0227@yeah.net
Received: November 22, 2024
Revised: March 4, 2025
Accepted: April 10, 2025
Published online: June 15, 2025
Processing time: 204 Days and 2.8 Hours
Core Tip

Core Tip: This comprehensive meta-analysis synthesizes data from randomized controlled trials to evaluate the impact of negative pressure wound therapy (NPWT) on diabetic foot ulcers, a prevalent and challenging complication in diabetic care. Our analysis not only reaffirms the efficacy of NPWT in enhancing wound healing rates and reducing amputation risks but also emphasizes its role in accelerating granulation tissue formation without increasing adverse events.