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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2023; 14(5): 594-605
Published online May 15, 2023. doi: 10.4239/wjd.v14.i5.594
Published online May 15, 2023. doi: 10.4239/wjd.v14.i5.594
Association of bone turnover biomarkers with severe intracranial and extracranial artery stenosis in type 2 diabetes mellitus patients
Si-Cong Si, Wei Yang, Hong-Yu Luo, Yi-Xin Ma, Huan Zhao, Jia Liu, General Geriatric Department, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
Author contributions: Si SC and Yang W contributed to the study conception and design; Liu J, Luo HY, Ma YX and Zhao H recruited patients and supervised the study process; Si SC analyzed the data and wrote the manuscript; and all authors read and approved the final article.
Supported by Beijing Municipal Hospital Management Center “Cultivation Plan” , No. PX2022032 .
Institutional review board statement: This study was approved by the Ethics Committees of Xuanwu Hospital of Capital Medical University.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: There are no conflicts of interest.
Data sharing statement: The data from this article will be provided by the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Yang, MD, Chief Doctor, General Geriatric Department, Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. yangw_79@163.com
Received: February 28, 2023
Peer-review started: February 28, 2023
First decision: March 14, 2023
Revised: March 20, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: May 15, 2023
Peer-review started: February 28, 2023
First decision: March 14, 2023
Revised: March 20, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: May 15, 2023
Core Tip
Core Tip: The occurrence of cerebral infarction is associated with severe intracranial and extracranial artery stenosis; thus, this study aims to identify risk factors for severe intracranial and extracranial artery stenosis in patients with type 2 diabetes mellitus (T2DM) to prevent the occurrence of cerebral infarction. Our study found that Bone turnover biomarkers (BTMs) are associated with the risk of arterial stenosis, probably due to the relationship between BTMs and glucose and lipid metabolism disorders. Detection of BTMs in patients with T2DM may help reduce the occurrence of cardiovascular disease.