Sebastian MJ, Khan SK, Pappachan JM, Jeeyavudeen MS. Diabetes and cognitive function: An evidence-based current perspective. World J Diabetes 2023; 14(2): 92-109 [PMID: 36926658 DOI: 10.4239/wjd.v14.i2.92]
Corresponding Author of This Article
Joseph M Pappachan, MD, FRCP, Consultant Endocrinologist, Professor, Senior Editor, Senior Researcher, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Feb 15, 2023; 14(2): 92-109 Published online Feb 15, 2023. doi: 10.4239/wjd.v14.i2.92
Diabetes and cognitive function: An evidence-based current perspective
Meghna Julian Sebastian, Shahanas KA Khan, Joseph M Pappachan, Mohammad Sadiq Jeeyavudeen
Meghna Julian Sebastian, School of Life Sciences, Keele University, Stoke-on-Trent ST5 5BG, United Kingdom
Shahanas KA Khan, Joseph M Pappachan, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom
Joseph M Pappachan, Faculty of Science, Manchester Metropolitan University, Manchester M15 6BH, United Kingdom
Joseph M Pappachan, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, United Kingdom
Mohammad Sadiq Jeeyavudeen, Department of Endocrinology and Metabolism, University Hospitals of Edinburgh, Edinburgh EH16 4SA, United Kingdom
Author contributions: Sebastian MJ and Khan SK performed the literature search, interpreted the relevant literature, and drafted the initial manuscript with guidance from Pappachan JM and Jeeyavudeen MS who conceived the idea and designed the paper; Jeeyavudeen MS prepared the figures and supervised the revision of the article critically for important intellectual content; and all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Joseph M Pappachan, MD, FRCP, Consultant Endocrinologist, Professor, Senior Editor, Senior Researcher, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Received: December 5, 2022 Peer-review started: December 5, 2022 First decision: December 26, 2022 Revised: December 26, 2022 Accepted: January 16, 2023 Article in press: January 16, 2023 Published online: February 15, 2023
Core Tip
Core Tip: Diabetes mellitus (DM) is a huge risk factor for cognitive dysfunction especially when the glycemic control is inadequate with marked hyperglycemia and recurrent hypoglycemia. Apart from cognitive decline inherent to the disease, presence of other forms of dementia can adversely affect diabetes control and consequently, negatively impact the care of dementia and DM. Appropriate control of DM with a multidisciplinary team approach involving diabetologists, dementia specialists, dieticians and physiotherapists should improve the clinical outcomes of either disease. Judicious and evidence-based adjustments in the antidiabetic medications appropriately tailored for individualised diabetes care with due consideration of patient’s age, severity of dementia and other comorbidities should help to improve care of patients with diabetes and dementia.
