Published online Nov 15, 2022. doi: 10.4239/wjd.v13.i11.900
Peer-review started: May 30, 2022
First decision: August 7, 2022
Revised: August 17, 2022
Accepted: October 11, 2022
Article in press: October 11, 2022
Published online: November 15, 2022
Core Tip: Type 2 diabetes (T2D) patients show increased susceptibility to bone fractures, despite their bone mineral density being normal or increased, leading to difficult identification for clinicians. The prevalence of T2D in adolescents and young adults is increasing alarmingly. Different researchers highlighted the mechanisms leading to bone fragility, and different critical altered pathways have been identified and studied. In this review, we described the different metabolic pathways responsible for bone fragility in patients with T2D. They can be useful for its management, although further studies are needed to deepen our understanding of the mechanisms underlying bone fragility in T2D.