Published online Apr 15, 2021. doi: 10.4239/wjd.v12.i4.366
Peer-review started: January 16, 2021
First decision: January 24, 2021
Revised: January 30, 2021
Accepted: February 18, 2021
Article in press: February 18, 2021
Published online: April 15, 2021
Core Tip: According to the developmental origin of health and disease concept, maternal obesity and neonatal accelerated growth predispose offspring to metabolic diseases. White adipose tissue and pancreatic β-cells are key targets of developmental programming, although the underlying mechanisms remain elusive. Human and rodent studies have contributed to decipher the role of epigenetic mechanisms in the transgenerational inheritance of obesity and type 2 diabetes (T2D). In this review, we discuss the current understanding of the link between obesogenic maternal nutritional environment, developmental epigenetic adipocyte and β-cell remodeling and predisposition to obesity and T2D later in life.