Mohamed IN, Li L, Ismael S, Ishrat T, El-Remessy AB. Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response. World J Diabetes 2021; 12(12): 1979-1999 [PMID: 35047114 DOI: 10.4239/wjd.v12.i12.1979]
Corresponding Author of This Article
Azza B El-Remessy, PharmD, PhD, Pharmacist, Department of Pharmacy, Doctors Hospital of Augusta, Wheeler Rd Augusta, GA 30909, United States. aelremessy@outlook.com
Research Domain of This Article
Pharmacology & Pharmacy
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Dec 15, 2021; 12(12): 1979-1999 Published online Dec 15, 2021. doi: 10.4239/wjd.v12.i12.1979
Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response
Islam N Mohamed, Luling Li, Saifudeen Ismael, Tauheed Ishrat, Azza B El-Remessy
Islam N Mohamed, Luling Li, Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, California North State University, Elk Grove, CA 95758, United States
Saifudeen Ismael, Tauheed Ishrat, Department of Anatomy and Neurobiology, and Neuroscience Institute, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States
Azza B El-Remessy, Department of Pharmacy, Doctors Hospital of Augusta, Augusta, GA 30909, United States
Author contributions: Mohamed IN, Li L, and Ismael S drafted the article; Ishrat T and El-Remessy AB critically edited the article and all authors reviewed the final version of the article.
Conflict-of-interest statement: The authors declare that they have no personal interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Azza B El-Remessy, PharmD, PhD, Pharmacist, Department of Pharmacy, Doctors Hospital of Augusta, Wheeler Rd Augusta, GA 30909, United States. aelremessy@outlook.com
Received: June 30, 2021 Peer-review started: June 30, 2021 First decision: July 28, 2021 Revised: September 1, 2021 Accepted: December 2, 2021 Article in press: December 2, 2021 Published online: December 15, 2021
Core Tip
Core Tip: Inflammation has been postulated as the central pathway involved in maintaining homeostasis and in cellular response to insults. High fat diet-induced inflammasome activation have been reported to predispose microvascular diseases including retinopathy, and nonalcoholic fatty liver disease. Inflammation can alter vascular recovery in response to ischemic insult including ischemic retinopathy, stroke and critical limb ischemia. Thioredoxin interacting protein (TXNIP) is required for the activation but not necessarily for expression of NOD-like receptor pyrin domain containing 3-inflammasome resulting in initiation or exacerbation of the disease state. A list of natural antioxidants or repurposed drugs is included to modulate TXNIP expression.
