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Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2020; 11(4): 115-125
Published online Apr 15, 2020. doi: 10.4239/wjd.v11.i4.115
Novel insight into perirenal adipose tissue: A neglected adipose depot linking cardiovascular and chronic kidney disease
Na Huang, En-Wen Mao, Ning-Ning Hou, Yong-Ping Liu, Fang Han, Xiao-Dong Sun
Na Huang, En-Wen Mao, Ning-Ning Hou, Yong-Ping Liu, Xiao-Dong Sun, Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Fang Han, Department of Pathology, Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Author contributions: Huang N contributed to review the literature, design and write the manuscript; Mao EW, Hou NN, Liu YP and Han F reviewed the literature; Sun XD designed the research and revised the manuscript.
Supported by National Natural Science Foundation of China, No. 81870593, No. 81600663.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Dong Sun, MD, PhD, Associate Professor, Doctor, Research Fellow, Department of Endocrinology, Affiliated Hospital of Weifang Medical University, 2428 Yuhe Road, Weifang 261031, Shandong Province, China. xiaodong.sun@wfmc.edu.cn
Received: December 28, 2019
Peer-review started: December 28, 2019
First decision: January 15, 2020
Revised: March 13, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 15, 2020
Core Tip

Core tip: The presence of excess perirenal adipose tissue, a neglected visceral adipose tissue, is regarded as an independent risk factor for both chronic kidney disease and cardiovascular disease. We herein discuss the relationship of perirenal adipose tissue in chronic kidney disease and cardiovascular disease, and the potential mechanism for perirenal adipose tissue participated in obesity-related disease.