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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2022; 13(3): 251-259
Published online Mar 15, 2022. doi: 10.4239/wjd.v13.i3.251
Published online Mar 15, 2022. doi: 10.4239/wjd.v13.i3.251
Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older
Xiao-Fang Bai, Qiao-Ling Zhao, Department of Ultrasound Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, Shannxi Province, China
Huan Wang, Department of Pain Medicine, The First Affiliated Hospital, Xi'an Jiao tong University, Xi'an 710061, Shannxi Province, China
Author contributions: Bai XF sorted out the data and wrote the draft; Wang H and Zhao QL revised the article.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The data that support the findings of this study are openly available by contacting the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiao-Ling Zhao, MD, PhD, Professor, Department of Ultrasound Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an 710061, Shaanxi Province, China. imagingzhaoql@126.com
Received: September 19, 2021
Peer-review started: September 19, 2021
First decision: November 8, 2021
Revised: December 6, 2021
Accepted: February 20, 2022
Article in press: February 20, 2022
Published online: March 15, 2022
Peer-review started: September 19, 2021
First decision: November 8, 2021
Revised: December 6, 2021
Accepted: February 20, 2022
Article in press: February 20, 2022
Published online: March 15, 2022
ARTICLE HIGHLIGHTS
Research background
The relationship between hemoglobin (Hb) and hemoglobin A1c (HbA1c) remains unclear.
Research motivation
To elucidate the relationship between Hb and HbA1c in a nondiabetic population aged ≥ 16 years in America.
Research objectives
To elucidate the relationship between Hb and HbA1c.
Research methods
The relationship was estimated using a multivariate regression.
Research results
Hb levels are negatively correlated with HbA1c.
Research conclusions
Normal Hb levels are negatively correlated with HbA1c in nondiabetic Americans aged ≥ 16 years.
Research perspectives
From a clinical point of view, HbA1c decreases by 0.08% for every 1 g/dL increase in Hb.