Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2021; 12(11): 1917-1927
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1917
Association between admission hemoglobin level and prognosis in patients with type 2 diabetes mellitus
Hai-Ying Song, Cui-Mei Wei, Wen-Xiong Zhou, Hao-Fei Hu, Qi-Jun Wan
Hai-Ying Song, Cui-Mei Wei, Wen-Xiong Zhou, Hao-Fei Hu, Qi-Jun Wan, Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518035, Guangdong Province, China
Hai-Ying Song, Cui-Mei Wei, Wen-Xiong Zhou, Hao-Fei Hu, Qi-Jun Wan, Department of Nephrology, Shenzhen University Health Science Center, Shenzhen 518035, Guangdong Province, China
Author contributions: Song HY, Hu HF, and Wan QJ contributed to the study concept and design, acquired and interpreted the data, and drafted the manuscript, and they are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis; Wei CM and Zhou WX cross-checked the data and reviewed the manuscript; Wei CM oversaw the progress of the project and contributed to the discussion; all authors read and approved the final manuscript.
Supported by the Research Project of Health and Family Planning Commission of Shenzhen Municipality, No. SZFZ2018063; Shenzhen Key Medical Discipline Construction Fund, No. SZXK009; Sanming Project of Medicine in Shenzhen, No. SZSM201512004; and Shenzhen Second People’s Hospital Clinical Research Fund of Guangdong Province High-level Hospital Construction Project, No. 20203357003 and No. 20213357018.
Institutional review board statement: The proposal was approved by the Clinical Research Ethical Committee of the Shenzhen Second People’s Hospital, and all subjects provided informed consent before enrollment. We adhered to the principles of the Declaration of Helsinki. The procedures followed were in accordance with institutional guidelines.
Informed consent statement: Informed consent statement was waived.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Jun Wan, PhD, Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, No. 3002 Sungang West Road, Futian District, Shenzhen 518035, Guangdong Province, China. yiyuan2224@sina.com
Received: February 5, 2021
Peer-review started: February 5, 2021
First decision: March 30, 2021
Revised: April 18, 2021
Accepted: October 11, 2021
Article in press: October 11, 2021
Published online: November 15, 2021
ARTICLE HIGHLIGHTS
Research background

Information on the association of hemoglobin with renal damage is uncertain, and the optimal hemoglobin target remains controversial.

Research motivation

The admission hemoglobin levels would influence the prognosis in patients with type 2 diabetes mellitus (T2DM).

Research objectives

To evaluate the relationships between admission hemoglobin levels and prognosis in patients with T2DM

Research methods

A total of 265 patients with T2DM were included to perform a retrospective analysis. The general information and biochemical indices of these patients were statistically analyzed.

Research results

We found a U-shaped relationship between hemoglobin levels and the composite endpoint. The curve tended to reach the lowest level at an optimal hemoglobin level.

Research conclusions

There is a U-shaped relationship between hemoglobin levels and renal damage in these patients.

Research perspectives

We used a retrospective study to evaluate the relationships between admission hemoglobin levels and prognosis in patients with T2DM.