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World J Diabetes. Jul 15, 2021; 12(7): 1093-1101
Published online Jul 15, 2021. doi: 10.4239/wjd.v12.i7.1093
Diabetes remission after bariatric surgery
Maryna Chumakova-Orin, Carolina Vanetta, Dimitrios P Moris, Alfredo D Guerron
Maryna Chumakova-Orin, Carolina Vanetta, Dimitrios P Moris, Alfredo D Guerron, Department of Surgery, Duke University, Durham, NC 27705, United States
Author contributions: Chumakova-Orin M, Vanetta C performed research and wrote the paper; Moris D and Guerron AD contributed critical revision of the manuscript for important intellectual content.
Conflict-of-interest statement: Authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dimitrios P Moris, MD, Academic Fellow, Research Fellow, Surgeon, Department of Surgery, Duke University, Durham, NC 27705, United States, 2301 ERWIN RD, Durham, NC 27705, United States. dimmoris@yahoo.com
Received: January 28, 2021
Peer-review started: January 28, 2021
First decision: May 3, 2021
Revised: May 10, 2021
Accepted: June 25, 2021
Article in press: June 25, 2021
Published online: July 15, 2021
Abstract

Over the last decade, obesity rates have continued to rise in the United States as well as worldwide and are showing no signs of slowing down. This rise is in parallel with the increasing rates of type 2 diabetes mellitus (T2DM). Given the association between obesity and T2DM and their strong correlation with increased morbidity and mortality in addition to healthcare expenditure, it is important to recognize the most effective ways to combat them. Thus, we performed a review of literature that focused on assessing the outcomes of T2DM following bariatric surgery. Available evidence suggests that bariatric surgery provides better T2DM resolution in obese patients when compared to best medical management alone. Additionally, Biliopancreatic diversion with duodenal switch as well as Roux-en-Y gastric bypass have demonstrated higher rates of T2DM resolution when compared with other bariatric procedures.

Keywords: Bariatric surgery, Diabetes, Remission, Gastric Bypass, Obesity

Core Tip: Bariatric surgery is a safe and effective way to achieve diabetes remission in those with obesity via a variety of mechanisms, the majority of which are independent of weight loss. Available evidence suggests that bariatric surgery provides better type 2 diabetes mellitus resolution in obese patients when compared to best medical management alone.