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©The Author(s) 2025.
World J Gastrointest Oncol. May 15, 2025; 17(5): 104229
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104229
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104229
Table 1 Distribution of hospital admissions for biliary tract cancers by type of diagnosis and year
| Year | Total | Intrahepatic CCA | Extrahepatic CCA | Gallbladder cancer and unspecified biliary tract |
| 2007 | 692 | 172 (24.9) | 239 (34.5) | 281 (40.6) |
| 2008 | 681 | 191 (28.0) | 259 (38.0) | 231 (33.9) |
| 2009 | 651 | 198 (30.4) | 225 (34.6) | 228 (35.0) |
| 2010 | 544 | 156 (28.7) | 197 (36.2) | 191 (35.1) |
| 2011 | 603 | 169 (28.0) | 232 (38.5) | 202 (33.5) |
| 2012 | 577 | 194 (33.6) | 192 (33.3) | 191 (33.1) |
| 2013 | 794 | 234 (29.5) | 268 (33.8) | 292 (36.8) |
| 2014 | 609 | 197 (32.3) | 202 (33.2) | 210 (34.5) |
| 2015 | 695 | 214 (30.8) | 222 (31.9) | 259 (37.3) |
| 2016 | 579 | 188 (32.5) | 182 (31.4) | 209 (36.1) |
| 2017 | 667 | 226 (33.9) | 213 (31.9) | 228 (34.2) |
| 2018 | 621 | 184 (29.6) | 194 (31.2) | 243 (39.1) |
| 2019 | 672 | 202 (30.1) | 217 (32.3) | 253 (37.6) |
| 2020 | 574 | 152 (26.5) | 183 (31.9) | 239 (41.6) |
| 2021 | 580 | 162 (27.9) | 180 (31.0) | 238 (41.0) |
| 2022 | 628 | 168 (26.8) | 180 (28.7) | 280 (44.6) |
| 2023 | 611 | 163 (26.7) | 198 (32.4) | 250 (40.9) |
| Total | 10778 | 3170 (29.4) | 3583 (33.2) | 4025 (37.3) |
Table 2 Description of the sample
| Characteristic | Total | Intrahepatic CCA | Extrahepatic CCA | Gallbladder cancer and unspecified biliary tract | P value |
| Gender | |||||
| Males | 5527 (51.3) | 1793 (56.6) | 1959 (54.7) | 1775 (44.1) | < 0.001 |
| Females | 5251 (48.7) | 1377 (43.4) | 1624 (45.3) | 2250 (55.9) | |
| Age group (years) | |||||
| 0-44 | 160 (1.5) | 68 (2.1) | 44 (1.2) | 48 (1.2) | < 0.001 |
| 45-54 | 547 (5.1) | 189 (6.0) | 165 (4.6) | 193 (4.8) | |
| 55-64 | 1615 (15.0) | 545 (17.2) | 441 (12.3) | 629 (15.6) | |
| 65-74 | 3184 (29.5) | 1027 (32.4) | 1000 (27.9) | 1157 (28.7) | |
| 75 + | 5272 (48.9) | 1341 (42.3) | 1933 (53.9) | 1998 (49.6) | |
| Age | 72.9 ± 11.3 | 71.3 ± 11.5 | 74.1 ± 11.1 | 73.2 ± 11.2 | < 0.001 |
| Hospital stay (days) | 16.9 ± 16.5 | 15.9 ± 15.5 | 18.1 ± 18.1 | 16.6 ± 16.5 | < 0.001 |
| Hospitalization regimen | |||||
| Ordinary | 9893 (91.8) | 2834 (89.4) | 3401 (94.9) | 3658 (90.9) | < 0.001 |
| Day surgery | 790 (7.3) | 326 (10.3) | 164 (4.6) | 300 (7.5) | |
| Week surgery | 95 (0.9) | 10 (0.3) | 18 (0.5) | 67 (1.7) | |
| Biliary tract cancer in main diagnosis | 8094 (75.1) | 2458 (77.5) | 2754 (76.9) | 2882 (71.6) | < 0.001 |
| Surgery during hospital stay | 9246 (85.8) | 2730 (86.1) | 3143 (87.7) | 3373 (83.8) | < 0.001 |
| In-hospital mortality | 1903 (17.7) | 574 (18.1) | 609 (17.0) | 720 (17.9) | NS |
| Total | 10778 (100.0) | 3170 (100.0) | 3583 (100.0) | 4025 (100.0) |
Table 3 Distribution of interventions by type of intervention and by age group
| Total | 0-44 | 45-54 | 55-64 | 65-74 | 75 + | In-hospital mortality | Total (n) |
| 150 (1.6) | 476 (5.1) | 1447 (15.7) | 2807 (30.4) | 4366 (47.2) | 1335 (14.4) | 9246 | |
| Digestive system interventions | 110 (1.7) | 341 (5.3) | 1014 (15.7) | 2000 (30.9) | 3000 (46.4) | 627 (9.7) | 6465 |
| Gallbladder and biliary tract procedures | 37 (1.2) | 121 (3.8) | 394 (12.3) | 829 (25.8) | 1826 (56.9) | 305 (9.5) | 3207 |
| Liver procedures | 43 (2.7) | 114 (7.2) | 326 (20.5) | 624 (39.3) | 481 (30.3) | 92 (5.8) | 1588 |
| Other abdominal region procedures | 15 (2.0) | 54 (7.1) | 150 (19.7) | 272 (35.7) | 271 (35.6) | 114 (15.0) | 762 |
| Incision, removal, and anastomosis of the intestine | 5 (1.0) | 26 (5.3) | 68 (13.7) | 133 (26.9) | 263 (53.1) | 74 (14.9) | 495 |
| Pancreas procedures | 6 (2.3) | 19 (7.3) | 50 (19.1) | 100 (38.2) | 87 (33.2) | 17 (6.5) | 262 |
| Other stomach procedures | 1 (1.0) | 2 (2.0) | 20 (20.2) | 28 (28.3) | 48 (48.5) | 18 (18.2) | 99 |
| Stomach incision and excision | 1 (5.9) | 1 (5.9) | 2 (11.8) | 5 (29.4) | 8 (47.1) | 2 (11.8) | 17 |
| Other bowel procedures | 1 (7.7) | 0 (0) | 1 (7.7) | 5 (38.5) | 6 (46.2) | 1 (7.7) | 13 |
| Procedures on the esophagus | 0 (0.0) | 2 (16.7) | 2 (16.7) | 2 (16.7) | 6 (50.0) | 3 (25.0) | 12 |
| Procedures on the rectum, rectosigmoid, and perirectal tissues | 0 (0.0) | 2 (33.3) | 1 (16.7) | 1 (16.7) | 2 (33.3) | 0 (0.0) | 6 |
| Hernia repair | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) | 2 |
| Procedures on the anus | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100) | 1 (100) | 1 |
| Appendix procedures | 1 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 |
| Diagnostic-therapeutic procedures | 31 (1.2) | 113 (4.4) | 384 (15.1) | 723 (28.5) | 1289 (50.7) | 682 (26.9) | 2540 |
| Other interventions | 9 (3.7) | 22 (9.1) | 49 (20.3) | 84 (34.9) | 77 (32.0) | 26 (10.8) | 241 |
- Citation: Baldo V, Cozza A, Grego V, Furlan P, Cozzolino C, Saia M, Cocchio S, Floreani A. Epidemiological trends of cholangiocarcinoma and gallbladder cancer in Northeastern Italy: Administrative analysis over a 17-year period (2007-2023). World J Gastrointest Oncol 2025; 17(5): 104229
- URL: https://www.wjgnet.com/1948-5204/full/v17/i5/104229.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.104229