Esophageal involvement of mantle cell lymphoma presenting with multiple lymphomatous polyposis: A single-center study

Figure 1 Esophageal findings of multiple lymphomatous polyposis. A: Contrast X-rays (case 1); multiple lymphomatous polyposis was recognized from the middle to lower esophagus; B-D: Esophagogastroduodenoscopy of case 2 (B), case 3 (C) and case 4 (D); E-G: Before (E) and after (F) chemotherapy in case 5, and case 6 (G); In case 5, multiple lymphomatous polyposis (MLP) disappeared after treatment. In case 6, inconspicuous MLP findings were observed.

Figure 2 Histopathological findings and fluorescence in situ hybridization in case 6. A: Low magnification (HE); B: High magnification (HE). Monotonous proliferation of small to medium-sized lymphoid cells was observed under the mucosa; C and D: CD5 (C) and cyclin D1 (D) was positive; E: IgH-BCL-1(CCND1) was strongly positive.

Figure 3 Endoscopic findings showing gastrointestinal involvement of mantle cell lymphoma. A: Stomach in case 1, protruded type; B: Stomach in case 2, multiple lymphomatous polyposis (MLP) type; C: Stomach in case 3, superficial type; D: Stomach in case 4, fold thickening and protruded type; E: Ileum in case 5, protruded type; F: Duodenum in case 6, MLP type.

Figure 4 Overall survival curves for the 6 patients (Kaplan-Meier method). The 50% survival period was less than 2 years, and the 5-year survival rate was approximately 30%.