Saito M, Oda Y, Sugino H, Suzuki T, Yokoyama E, Kanaya M, Izumiyama K, Mori A, Morioka M, Kondo T. Esophageal involvement of mantle cell lymphoma presenting with multiple lymphomatous polyposis: A single-center study. World J Gastrointest Oncol 2025; 17(5): 105448 [DOI: 10.4251/wjgo.v17.i5.105448]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Makoto Saito, Toma Suzuki, Emi Yokoyama, Minoru Kanaya, Koh Izumiyama, Akio Mori, Masanobu Morioka, Takeshi Kondo, Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan
Yoshitaka Oda, Hirokazu Sugino, Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan
Author contributions: Saito M designed this study and wrote the manuscript; Oda Y and Sugino H involved in pathological procedure in this study; all authors made substantial contributions to acquisition of data, or analysis and interpretation of data; all authors took part in drafting the article; all authors agree to be accountable for all aspects of the work.
Institutional review board statement: This study followed the principles of the Declaration of Helsinki and was approved by the Aiiku Hospital Clinical Research Review Board (No. 2024 2181).
Informed consent statement: Five of the six patients had already died at the time the current study was planned. Furthermore, due to the retrospective nature of the study, the need for informed consent was waived by the Aiiku Hospital Clinical Research Review Board. Nevertheless, written informed consent was obtained from the remaining, currently surviving patient (case 6) for publication of any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest in this study.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: January 23, 2025 Revised: February 28, 2025 Accepted: March 26, 2025 Published online: May 15, 2025 Processing time: 113 Days and 1.9 Hours
Abstract
BACKGROUND
In addition to nodal lesions, over 30% of mantle cell lymphomas (MCLs) also have gastrointestinal involvement, characteristically presenting as multiple lymphomatous polyposis (MLP), which rarely involve the esophagus. Most related papers have been case reports, and no comprehensive studies have been conducted; thus, the actual clinical situation has remained unknown for a long time.
AIM
To elucidate the actual clinical situation of esophageal involvement of MCL presenting with MLP, including its prognosis.
METHODS
From January 2001 to December 2021, among MCL patients whose gastrointestinal lesions were histopathologically confirmed by endoscopic biopsy at our center, 6 patients with MLP in the esophagus were selected. We retrospectively examined the clinical features of these patients, including their prognosis.
RESULTS
In all patients, multiple lesions were present in the gastrointestinal tract other than the esophagus and in the lymph nodes throughout the body, and most patients also had lesions involving the bone marrow or spleen. Most of the treatments include chemotherapy, with a 50% survival period of less than 2 years and a 5-year survival rate of approximately 30%, indicating a poor prognosis.
CONCLUSION
Patients with esophageal involvement of the MCL who presented with MLP had a large tumor burden and poor survival.
Core Tip: Multiple lymphomatous polyposis, a main characteristic form of gastrointestinal involvement of mantle cell lymphoma, rarely affects the esophagus; the clinical status of this condition, including survival prognosis, has long remained unknown. In this study, we selected 6 patients and retrospectively examined their clinical features. In all patients, multiple lesions were present in the gastrointestinal tract other than the esophagus and in lymph nodes throughout the body, and most patients had lesions involving the bone marrow or spleen. The median survival time was less than 2 years, and the 5-year survival rate was approximately 30%, indicating a poor prognosis.
