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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2025; 17(8): 108007
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.108007
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.108007
Tumor markers and multimodal magnetic resonance imaging in predicting rectal cancer stage and differentiation
Peng Wang, Department of Infectious Diseases, First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China
Jun Han, Wen-Na Zhao, Fan Wu, Sheng-He Zhang, Yi-Juan Huang, Department of Radiology, First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China
Co-first authors: Peng Wang and Jun Han.
Author contributions: Wang P and Han J conducted the conceptualization, data organization, methodology, software, and writing of the original manuscript; they contributed equally to this article and are the co-first authors of this manuscript; Zhao WN, Wu F, and Zhang SH performed formal analysis, project management, and visualization; Huang YJ performed research, supervision, validation, writing, review and editing; all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Zhejiang Provincial Natural Science Foundation of China, No. LTGY24H160006; and Jiaxing Medical Key Discipline, No. 2023-ZC-015.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Jiaxing First Hospital Committee, approval No. 2025-LP-215.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrollment.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Data sharing statement: The technical appendix, statistical code, and dataset are available from the corresponding author at huangyijuan2006@zjxu.edu.cn. Participants gave informed consent for data sharing.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Juan Huang, MD, Department of Radiology, First Hospital of Jiaxing, No. 1882 Central South Road, Nanhu District, Jiaxing 314000, Zhejiang Province, China. huangyijuan2006@zjxu.edu.cn
Received: April 22, 2025
Revised: May 23, 2025
Accepted: July 8, 2025
Published online: August 15, 2025
Processing time: 113 Days and 15.6 Hours
Revised: May 23, 2025
Accepted: July 8, 2025
Published online: August 15, 2025
Processing time: 113 Days and 15.6 Hours
Core Tip
Core Tip: This study included 167 rectal cancer patients who underwent serological tests and multimodal magnetic resonance imaging. Results showed significant concordance between magnetic resonance imaging and pathological T-staging. Combined use of tumor markers (alpha-fetoprotein cancer antigen 72-4, carbohydrate antigen 19-9, and carcinoembryonic antigen) and magnetic resonance imaging had high sensitivity/specificity for staging/differentiation, outperforming single tests, thus enhancing diagnostic accuracy for clinical practice.