Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2025; 17(8): 106781
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.106781
GEN1 regulates cell proliferation, migration, apoptosis and ferroptosis in gastric cancer
Qi Zhang, Zu-Guo Yuan, Kai-Feng Zheng, Ke Chen
Qi Zhang, Department of Gastroenterology, The Affiliated People’s Hospital of Ningbo University, Ningbo 315000, Zhejiang Province, China
Zu-Guo Yuan, Kai-Feng Zheng, Ke Chen, Chemoradiotherapy Center of Oncology, The Affiliated People’s Hospital of Ningbo University, Ningbo 315000, Zhejiang Province, China
Author contributions: Zhang Q contributed to conception and design, analysis and interpretation, critical revision of the article and final approval of the article; Yuan ZG contributed to data collection; Zheng KF and Chen K contributed to writing the article; All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the ethics committee of The Affiliated People’s Hospital of Ningbo University (No. 2023010901).
Institutional animal care and use committee statement: This study does not involve any animal experiments.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi Zhang, MD, Doctor, Department of Gastroenterology, The Affiliated People’s Hospital of Ningbo University, No. 251 Baizhang East Road, Ningbo 315000, Zhejiang Province, China. matin219@163.com
Received: April 8, 2025
Revised: May 8, 2025
Accepted: June 20, 2025
Published online: August 15, 2025
Processing time: 127 Days and 20.8 Hours
Core Tip

Core Tip: GEN1 promotes gastric cancer (GC) cell proliferation and migration while suppressing apoptosis and ferroptosis. Targeting GEN1 not only disrupts mitochondrial function and cell cycle progression but also sensitizes GC cells to ferroptosis and chemotherapy. These findings highlight GEN1 as a potential therapeutic target for enhancing treatment efficacy in GC.