Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2025; 17(5): 105933
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.105933
Circular RNA hsa_circRNA_101996 modulates gastric cancer cell proliferation and apoptosis through the miR-577/HMGN5 axis
Xiao-Lei Wang, Lin Zhang, Qing Shang
Xiao-Lei Wang, Qing Shang, Department of General Surgery, Xinxiang Central Hospital, Xinxiang 453000, Henan Province, China
Lin Zhang, Department of Oncology, The First People's Hospital of Changshu, Suzhou 215501, Jiangsu Province, China
Author contributions: Wang XL designed the research study; Zhang L and Shang Q performed the research; all authors analyzed the data and wrote the manuscript and have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Xinxiang Central Hospital Institutional Review Board (Approval No. 2023-227).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Ethical Committees of Xinxiang Central Hospital (Protocol No. 2024-KY-0723-001).
Conflict-of-interest statement: Dr. Wang has nothing to disclose.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at wangx1305@163.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Lei Wang, PhD, Department of General Surgery, Xinxiang Central Hospital, No. 56 Jinsui Avenue, Xinxiang 453000, Henan Province, China. wangxl305@163.com
Received: February 11, 2025
Revised: March 19, 2025
Accepted: March 20, 2025
Published online: May 15, 2025
Processing time: 93 Days and 16.8 Hours
Core Tip

Core Tip: This study reveals that circRNA_101996 promotes gastric cancer progression by sponging microRNA-577 (miR-577) to upregulate high mobility group nucleosome binding domain 5, thereby enhancing cell proliferation and inhibiting apoptosis. This study identifies a novel regulatory mechanism of circRNA_101996 in gastric cancer pathogenesis.