Miao LF, Sun YY, Du XJ, Xu N, Shen JW, Hua H, Guo M, Yang HJ, Li JK, Zhu L. Combined detection of P53, Ki67, P504S, and IMP3: Diagnostic implications for gastric cancer and precursor lesions. World J Gastrointest Oncol 2025; 17(5): 105604 [DOI: 10.4251/wjgo.v17.i5.105604]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. May 15, 2025; 17(5): 105604 Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.105604
Combined detection of P53, Ki67, P504S, and IMP3: Diagnostic implications for gastric cancer and precursor lesions
Lan-Fang Miao, Yuan-Yuan Sun, Xian-Juan Du, Nan Xu, Jing-Wei Shen, Hui Hua, Mei Guo, Hai-Jun Yang, Jun-Kuo Li, Lei Zhu
Lan-Fang Miao, Yuan-Yuan Sun, Xian-Juan Du, Nan Xu, Jing-Wei Shen, Hui Hua, Mei Guo, Hai-Jun Yang, Jun-Kuo Li, Department of Pathology, Anyang Tumor Hospital, Anyang 455000, Henan Province, China
Lan-Fang Miao, Yuan-Yuan Sun, Xian-Juan Du, Nan Xu, Jing-Wei Shen, Hui Hua, Mei Guo, Hai-Jun Yang, Jun-Kuo Li, Department of Pathology, The Affiliated Anyang Tumor Hospital of Henan University of Science and Technology, Anyang 455000, Henan Province, China
Lei Zhu, Department of Pathology, Anyang Sixth People's Hospital, Anyang 455000, Henan Province, China
Author contributions: Miao LF conceived the research; Miao LF and Du XJ collected the clinical data; Sun YY, Xu N, Zhu L, Shen JW, and Hua H contributed to the reagents/materials/analysis tools; Miao LF wrote the original draft; Yang HJ, Guo M, and Li JK reviewed and edited the manuscript; all authors have read and approved the submitted version.
Supported by The Science and Technology Research Project of Anyang, No. 2022C01SF074.
Institutional review board statement: The ethics committee of Anyang Tumor Hospital approved this study (No. 2023KY16H01).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and/or analyzed in the current study presented in the study are included in the article/supplementary information section. Further inquiries can be directed to the corresponding author (Lan-Fang Miao, E-mail: lanfang_miao@163.com) upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: January 30, 2025 Revised: March 11, 2025 Accepted: April 18, 2025 Published online: May 15, 2025 Processing time: 105 Days and 22.3 Hours
Core Tip
Core Tip: The combined detection of P504S and Ki67 for low-grade dysplasia (LGD), and IMP3 and P53 for high-grade dysplasia (HGD) and adenocarcinoma (AC), enhances diagnostic sensitivity, aiding in the differentiation of gastric cancer and its precancerous lesions, thereby improving early cancer diagnosis. The immunohistochemical markers P504S, Ki67, IMP3, and P53 are valuable in distinguishing gastric lesions, including atypical hyperplasia, LGD, HGD, and AC. P504S is predominantly expressed in LGD and shows a correlation with the Ki67 “polarity” expression pattern, while IMP3 is highly expressed in HGD/AC and correlates with the P53 mutation pattern. The combined detection of P504S with Ki67 and IMP3 with P53 significantly enhances the diagnostic sensitivity for LGD and HGD/AC, respectively, aiding in the early detection of gastric cancer and its precancerous lesions. This approach can improve the accuracy of pathological diagnoses, thereby facilitating timely intervention.
