Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2025; 17(5): 105192
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.105192
Significance of serum APE1-AAbs, PTX-3, and miR-486-3p in patients with colorectal cancer undergoing radical surgery
Hao Wang, Wei Wang
Hao Wang, Advanced Medical Research Institute, Shandong University, Jinan 250012, Shandong Province, China
Wei Wang, Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan 250000, Shandong Province, China
Co-first authors: Hao Wang and Wei Wang.
Author contributions: Wang H designed the research study and performed the research; Wang W conducted the experiments and analyzed the data; Wang H and Wang W contributed to editorial changes in the manuscript, read and approved the final manuscript, and contributed equally as co-first authors.
Institutional review board statement: This study was approved by the Ethics Committee of Shandong Advanced Medical Research Institute.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Wang, Chief Physician, Department of Interventional Medicine, The Second Hospital of Shandong University, No. 247 Beiyuan Street, Jinan 250000, Shandong Province, China. xtx442@yeah.net
Received: January 15, 2025
Revised: February 17, 2025
Accepted: March 21, 2025
Published online: May 15, 2025
Processing time: 121 Days and 4.5 Hours
Core Tip

Core Tip: Serum apurinic/apyrimidinic endonuclease 1 autoantibodies, peripheral pentraxin-3, and miR-486-3p levels are higher in colorectal cancer patients with postoperative recurrence and metastasis. These three markers are risk factors for postoperative recurrence and metastasis in colorectal cancer and can be used as predictive biomarkers. The combined detection of these markers has higher predictive value compared to individual tests.