Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2025; 17(5): 105192
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.105192
Significance of serum APE1-AAbs, PTX-3, and miR-486-3p in patients with colorectal cancer undergoing radical surgery
Hao Wang, Wei Wang
Hao Wang, Advanced Medical Research Institute, Shandong University, Jinan 250012, Shandong Province, China
Wei Wang, Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan 250000, Shandong Province, China
Co-first authors: Hao Wang and Wei Wang.
Author contributions: Wang H designed the research study and performed the research; Wang W conducted the experiments and analyzed the data; Wang H and Wang W contributed to editorial changes in the manuscript, read and approved the final manuscript, and contributed equally as co-first authors.
Institutional review board statement: This study was approved by the Ethics Committee of Shandong Advanced Medical Research Institute.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Wang, Chief Physician, Department of Interventional Medicine, The Second Hospital of Shandong University, No. 247 Beiyuan Street, Jinan 250000, Shandong Province, China. xtx442@yeah.net
Received: January 15, 2025
Revised: February 17, 2025
Accepted: March 21, 2025
Published online: May 15, 2025
Processing time: 121 Days and 4.5 Hours
Abstract
BACKGROUND

Colorectal cancer (CRC) is a common malignant tumor of the digestive tract worldwide, characterized by high incidence and mortality rates.

AIM

To investigate the expression of serum apurinic/apyrimidinic endonuclease 1 autoantibodies (APE1-AAbs), peripheral pentraxin-3 (PTX-3), and miR-486-3p in patients with CRC undergoing radical surgery and their relationship with postoperative recurrence and metastasis.

METHODS

A retrospective analysis was conducted on the clinical data of 154 CRC patients who underwent laparoscopic radical surgery in our hospital from January 2022 to January 2024. Patients were followed for one year postoperatively and divided into an occurrence group (n = 28) and a non-occurrence group (n = 126) based on whether they experienced recurrence or metastasis. The clinical data and the expression levels of APE1-AAbs, PTX-3, and miR-486-3p were compared between the two groups. Multivariate logistic regression analysis was performed to identify risk factors for postoperative recurrence and metastasis in CRC patients. The relationship of APE1-AAbs, PTX-3, and miR-486-3p with postoperative recurrence and metastasis was analyzed using Spearman correlation analysis. Receiver operating characteristic curves were drawn to evaluate the predictive value of serum APE1-AAbs, PTX-3, and miR-486-3p levels alone and their combination for postoperative recurrence and metastasis in CRC.

RESULTS

The occurrence group had significantly higher proportions of patients with an age ≥ 60 years, lymph node metastasis, stage III disease, poor differentiation, tumor diameter > 5 cm, and higher platelet count, carcinoembryonic antigen, and carbohydrate antigen 19-9 levels than the non-occurrence group (P < 0.05). The expression levels of APE1-AAbs, PTX-3, and miR-486-3p in the occurrence group were significantly higher than those in the non-occurrence group (P < 0.05). Multivariate logistic regression analysis showed that lymph node metastasis, stage III disease, poor differentiation, and elevated levels of APE1-AAbs, PTX-3, and miR-486-3p were risk factors for postoperative recurrence and metastasis in CRC patients (odds ratio > 1, P < 0.05). Spearman correlation analysis revealed that the levels of APE1-AAbs, PTX-3, and miR-486-3p were positively correlated with postoperative recurrence and metastasis in CRC patients (r = 0.642, 0.653, and 0.631, respectively, P < 0.05). Receiver operating characteristic curve analysis showed that the area under the curve values for APE1-AAbs, PTX-3, and miR-486-3p levels alone and their combination in predicting postoperative recurrence and metastasis in CRC were 0.764, 0.783, 0.806, and 0.875, respectively, with the combination significantly outperforming individual markers (P < 0.05).

CONCLUSION

Serum APE1-AAbs, PTX-3, and miR-486-3p levels are higher in CRC patients with postoperative recurrence and metastasis. These three markers are risk factors for postoperative recurrence and metastasis in CRC and can be used as predictive biomarkers. The combined detection of these markers has higher predictive value compared to individual tests.

Keywords: Apurinic/apyrimidinic endonuclease 1 autoantibodies; Peripheral pentraxin-3; MiR-486-3p; Colorectal cancer; Laparoscopic radical surgery; Postoperative recurrence and metastasis; Risk factors; Predictive value

Core Tip: Serum apurinic/apyrimidinic endonuclease 1 autoantibodies, peripheral pentraxin-3, and miR-486-3p levels are higher in colorectal cancer patients with postoperative recurrence and metastasis. These three markers are risk factors for postoperative recurrence and metastasis in colorectal cancer and can be used as predictive biomarkers. The combined detection of these markers has higher predictive value compared to individual tests.