Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2022; 14(12): 2329-2339
Published online Dec 15, 2022. doi: 10.4251/wjgo.v14.i12.2329
Published online Dec 15, 2022. doi: 10.4251/wjgo.v14.i12.2329
Expression of nucleus accumbens-1 in colon cancer negatively modulates antitumor immunity
Zhao-Hua Shen, Wei-Wei Luo, Xiao-Yan Wang, Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
Xing-Cong Ren, Jin-Ming Yang, Department of Cancer Biology and Toxicology, University of Kentucky College of Medicine, Lexington, MA 40506, United States
Author contributions: Yang JM and Wang XY supervised the project and revised the manuscript; Shen ZH performed the in vitro and in vivo experiments, generated the figures, and revised the manuscript; Luo WW completed the analysis of the results; Ren XC contributed to the study design.
Supported by the Changsha Municipal Natural Science Foundation , No. kq2014258 .
Institutional review board statement: The study was reviewed and approved by the IRB of Third Xiangya Hospital, Central South University (Approval No. 2020-S195).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the IRB of Third Xiangya Hospital, Central South University (No. 2020-S298).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: Data can be acquired from the corresponding author.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Ming Yang, Doctor, Academic Editor, Department of Cancer Biology and Toxicology, University of Kentucky College of Medicine, 101 Main Building Lexington, MA 40506, United States. yangjinming285@sina.com
Received: July 10, 2022
Peer-review started: July 10, 2022
First decision: September 26, 2022
Revised: October 16, 2022
Accepted: November 21, 2022
Article in press: November 21, 2022
Published online: December 15, 2022
Peer-review started: July 10, 2022
First decision: September 26, 2022
Revised: October 16, 2022
Accepted: November 21, 2022
Article in press: November 21, 2022
Published online: December 15, 2022
Core Tip
Core Tip: We determined whether and how nucleus accumbens-1 (NAC-1) affects antitumor immunity in colon cancer. Knockdown of NAC-1 expression in colon cancer cells significantly enhanced the cytocidal effect of CD8+ T cells. Knockdown of NAC-1 in colon cancer cells decreased the expression of progra