Clinical and Translational Research
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2023; 15(1): 90-101
Published online Jan 15, 2023. doi: 10.4251/wjgo.v15.i1.90
Network pharmacology-based analysis of heat clearing and detoxifying drug JC724 on the treatment of colorectal cancer
Hua-Zhen Tang, Zhen-Peng Yang, Shuai Lu, Bing Wang, Yu-Ying Wang, Xi-Bo Sun, Jin-Xiu Qu, Ben-Qiang Rao
Hua-Zhen Tang, Zhen-Peng Yang, Shuai Lu, Bing Wang, Yu-Ying Wang, Xi-Bo Sun, Jin-Xiu Qu, Ben-Qiang Rao, Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Hua-Zhen Tang, Zhen-Peng Yang, Shuai Lu, Bing Wang, Yu-Ying Wang, Jin-Xiu Qu, Ben-Qiang Rao, Department of Gastrointestinal Surgery, Key Laboratory of Cancer FSMP for State Market Regulation, Beijing 100038, China
Xi-Bo Sun, Department of Breast Surgery, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, Shandong Province, China
Author contributions: Tang HZ and Yang ZP designed this study; Yang ZP, Lu S, Wang B and Qu JX performed the literature review and collected the data; Tang HZ, Wang YY and Sun XB analyzed the data; Tang HZ drafted the manuscript; Rao BQ reviewed the manuscript critically; all authors contributed to editing and approved the final manuscript version.
Supported by The National Natural Science Foundation of China, No. 82074061; and Beijing Natural Science Foundation Proposed Program, No. 7202076.
Institutional review board statement: The study was reviewed and approved by the Beijing Shijitan Hospital, Capital Medical University Institutional Review Board [Approval No. sjtkyll-lx-2021(41)].
Conflict-of-interest statement: The authors declare no conflicts of financial and non-financial competing interests.
Data sharing statement: The data used in the study is available upon request to the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ben-Qiang Rao, DPhil, PhD, Associate Chief Physician, Professor, Surgeon, Surgical Oncologist, Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian, Haidian District, Beijing 100038, China. raobenqiang@bjsjth.cn
Received: September 30, 2022
Peer-review started: September 30, 2022
First decision: October 21, 2022
Revised: October 28, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 15, 2023
ARTICLE HIGHLIGHTS
Research background

Heat clearing and detoxification drugs are commonly used in traditional Chinese medicine to treat colorectal cancer, but the mechanism is not clear.

Research motivation

We hope that our study can provide a new perspective to the anti-cancer mechanism of heat-clearing and detoxifying therapy, and bring new drugs for the treatment of colorectal cancer (CRC).

Research objectives

This study aims to systematically explore the anticancer mechanism of heat clearing and detoxifying drug JC724.

Research methods

We identified JC724 active components and targets by database, and then determined CRC related targets through the database and transcriptome analysis. We used network pharmacology to analyze the active herbal ingredients, core targets and main mechanisms of JC724 in the treatment of CRC.

Research results

We found that the five ingredients with the most targets were quercetin, β Beta sitosterol, wogonin, kaempferol and baicalein, which were the core ingredients. The core JC724-CRC targets were CYP1A1, HMOX1, CXCL8, NQO1 and FOSL1. JC724 mainly acts on CRC through Nrf2 signaling pathway, oxidative stress and IL-17 signaling pathway.

Research conclusions

This study systematically analyzed the mechanism of heat clearing and detoxification drug JC724 in the treatment of CRC, providing direction for further experiments.

Research perspectives

This study provides a new perspective on the anti-cancer mechanism of heat clearing and detoxifying drug drugs. Combined with the theory of traditional Chinese medicine, this study can provide direction for research and clinical treatment in the future.