Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2019; 11(12): 1115-1125
Published online Dec 15, 2019. doi: 10.4251/wjgo.v11.i12.1115
Improved method for inducing chronic atrophic gastritis in mice
Xian Wei, Xue-Ping Feng, Lu-Yao Wang, Yan-Qiang Huang, Ling-Ling Liang, Xiao-Qiang Mo, Hong-Yu Wei
Xian Wei, Xue-Ping Feng, Lu-Yao Wang, Yan-Qiang Huang, Ling-Ling Liang, Xiao-Qiang Mo, Hong-Yu Wei, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
Author contributions: Wei X and Feng XP performed the research and contributed equally to this work; Wang LY, Liang LL, Mo XQ, and Wei HY analyzed the data; Huang YQ designed the research and analyzed the data; all authors drafted the article, made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published.
Supported by National Natural Science Foundation of China, No. 31460023; Science Research and Technology Development Project of Guangxi, No. 1598025-33.
Institutional review board statement: All specimens from the patients were obtained after informed consent and ethical permission were obtained for participation in the study.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yan-Qiang Huang, MD, PhD, Professor, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, No. 98, Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com
Telephone: +86-776-2849490 Fax: +86-776-2853272
Received: May 16, 2019
Peer-review started: May 21, 2019
First decision: July 31, 2019
Revised: August 5, 2019
Accepted: October 1, 2019
Article in press: October 1, 2019
Published online: December 15, 2019
ARTICLE HIGHLIGHTS
Research background

Chronic atrophic gastritis (CAG) is a precancerous lesion of gastric cancer. If it is effectively treated, GC will be prevented. So the prevention and treatment of CAG are very important. It needs a good animal model, which can provide etiological research and screening of therapeutic drugs. It is an important tool for studying CAG.

Research motivation

Current animal models of chronic atrophic gastritis are not ideal, long cycle, high cost, difficult to operate, and unstable, so better animal models are needed.

Research objectives

To construct a more rapid, safe, stable and efficient chronic atrophic gastritis model with mice.

Research methods

The mice selected for this method were six-week-old Kunming mice, and Helicobacter pylori, N-methyl-N'-nitroguanidine, and ammonia water were combined to develop a CAG model.

Research results

The method showed slight CAG at the 90th day and moderate CAG at the 120th day.

Research conclusions

The method presented here is more rapid, safe, stable, and efficient.

Research perspectives

Starting from the etiology of chronic atrophic gastritis, the course of the disease is simulated to explore a simple, fast, convenient, and stable method of modelling.