Published online Dec 15, 2019. doi: 10.4251/wjgo.v11.i12.1115
Peer-review started: May 21, 2019
First decision: July 31, 2019
Revised: August 5, 2019
Accepted: October 1, 2019
Article in press: October 1, 2019
Published online: December 15, 2019
Chronic atrophic gastritis (CAG) is a precancerous lesion of gastric cancer. If it is effectively treated, GC will be prevented. So the prevention and treatment of CAG are very important. It needs a good animal model, which can provide etiological research and screening of therapeutic drugs. It is an important tool for studying CAG.
Current animal models of chronic atrophic gastritis are not ideal, long cycle, high cost, difficult to operate, and unstable, so better animal models are needed.
To construct a more rapid, safe, stable and efficient chronic atrophic gastritis model with mice.
The mice selected for this method were six-week-old Kunming mice, and Helicobacter pylori, N-methyl-N'-nitroguanidine, and ammonia water were combined to develop a CAG model.
The method showed slight CAG at the 90th day and moderate CAG at the 120th day.
The method presented here is more rapid, safe, stable, and efficient.
Starting from the etiology of chronic atrophic gastritis, the course of the disease is simulated to explore a simple, fast, convenient, and stable method of modelling.