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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2019; 11(12): 1115-1125
Published online Dec 15, 2019. doi: 10.4251/wjgo.v11.i12.1115
Published online Dec 15, 2019. doi: 10.4251/wjgo.v11.i12.1115
Improved method for inducing chronic atrophic gastritis in mice
Xian Wei, Xue-Ping Feng, Lu-Yao Wang, Yan-Qiang Huang, Ling-Ling Liang, Xiao-Qiang Mo, Hong-Yu Wei, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
Author contributions: Wei X and Feng XP performed the research and contributed equally to this work; Wang LY, Liang LL, Mo XQ, and Wei HY analyzed the data; Huang YQ designed the research and analyzed the data; all authors drafted the article, made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published.
Supported by National Natural Science Foundation of China , No. 31460023 ; Science Research and Technology Development Project of Guangxi , No. 1598025-33 .
Institutional review board statement: All specimens from the patients were obtained after informed consent and ethical permission were obtained for participation in the study.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yan-Qiang Huang, MD, PhD, Professor, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, No. 98, Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com
Telephone: +86-776-2849490 Fax: +86-776-2853272
Received: May 16, 2019
Peer-review started: May 21, 2019
First decision: July 31, 2019
Revised: August 5, 2019
Accepted: October 1, 2019
Article in press: October 1, 2019
Published online: December 15, 2019
Peer-review started: May 21, 2019
First decision: July 31, 2019
Revised: August 5, 2019
Accepted: October 1, 2019
Article in press: October 1, 2019
Published online: December 15, 2019
Core Tip
Core tip: A chronic atrophic gastritis (CAG) model was successfully established at the 90th day after the last Helicobacter pylori (H. pylori) infection of six-week-old mice, with a success rate reaching 90%. The method overcomes the difficulty in colonising H. pylori in mice and the fact that the colonisation time is short. In addition, rats are replaced with mice, and the method is thus simpler and also cheaper. The established models are stable and safe, therefore, the method is a relatively ideal method for establishing a mouse model of CAG. It provides a significant help when exploring the mechanisms of occurrence and prevention CAG.