Xu S, Xu M. Advances in diagnosis and treatment of gallbladder cancer: Current status and future directions. World J Gastrointest Oncol 2025; 17(5): 104957 [DOI: 10.4251/wjgo.v17.i5.104957]
Corresponding Author of This Article
Ming Xu, PhD, Postdoctoral Fellow, Senior Researcher, Department of Hepatic-Biliary-Pancreatic Surgery, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Bengbu 233000, Anhui Province, China. jatxuming@163.com
Research Domain of This Article
Developmental Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. May 15, 2025; 17(5): 104957 Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104957
Advances in diagnosis and treatment of gallbladder cancer: Current status and future directions
Song Xu, Ming Xu
Song Xu, Department of Hepatobiliary Surgery, Shangyu People’s Hospital of Shaoxing, Shaoxing 312300, Zhejiang Province, China
Ming Xu, Department of Hepatic-Biliary-Pancreatic Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China
Author contributions: Xu S wrote the manuscript; Xu M guided the study; and all authors were involved in study supervision and reviewed and endorsed the manuscript.
Supported by the Program for Young Backbone Teachers in the Universities of Anhui Province, No. JNFX2023031.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming Xu, PhD, Postdoctoral Fellow, Senior Researcher, Department of Hepatic-Biliary-Pancreatic Surgery, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Bengbu 233000, Anhui Province, China. jatxuming@163.com
Received: January 7, 2025 Revised: March 7, 2025 Accepted: March 18, 2025 Published online: May 15, 2025 Processing time: 128 Days and 9.2 Hours
Abstract
Gallbladder cancer (GBC) is a rare but aggressive cancer that often presents subtle early symptoms, leading to late-stage diagnosis. In recent years, significant advancements have been made in early detection and treatment of GBC. These improvements are driven by a better understanding of the risk factors for this malignancy and the use of new diagnostic technologies. This review systematically examines the risk factors associated with GBC, and advancements in diagnostic techniques and treatment strategies, with an aim to enhance the early diagnosis and effective management of GBC to provide a valuable reference for clinical practice.
Core Tip: Gallbladder cancer is a rare but aggressive malignancy often diagnosed at advanced stages due to subtle early symptoms, resulting in poor survival rates and significant socio-economic burdens. This paper aims to enhance early diagnosis and effective management strategies for gallbladder cancer by systematically reviewing the current literature on risk factors, innovative diagnostic techniques, and treatment options.
