Published online Jun 15, 2019. doi: 10.4251/wjgo.v11.i6.459
Peer-review started: February 12, 2019
First decision: March 15, 2019
Revised: April 6, 2019
Accepted: April 19, 2019
Article in press: April 20, 2019
Published online: June 15, 2019
Circular RNA (circRNA) is a newly discovered non-coding RNA with special structure, which is widely expressed in eukaryotic organisms and mainly located in the cytoplasm. circRNAs participate in gene regulation by working as miRNA sponges that block the inhibitory effect of miRNA on its target genes. In addition, circRNAs can bind to RNA binding proteins to regulate gene expression. Based on characteristics of stability, expression specificity and participation in gene regulation, circRNAs are expected to be biomarkers for early diagnosis of cancer or potential targets for cancer therapy. With the help of bioinformatics analysis, circRNA microarray analysis and high-throughput sequencing technology, more circRNAs were discovered to participate in the progression of gastric cancer (GC) over the past three years. This article gives an overview of these recent research focusing on the roles of circRNAs in GC and highlights the advances.
Core tip: Gastric cancer (GC) is a common, worldwide malignant tumor with a poor prognosis. An increasing number of circRNAs was discovered to participate in the progression of GC. Therefore, exploring the function of circRNAs will help to achieve a better understanding of the pathogenesis of GC and identify new diagnostic biomarkers and therapeutic targets. This article gives an overview of the recent research focusing on the roles of circRNAs in GC and highlights the advances that were made over the past three years.