Osteoclastic and pleomorphic giant cell tumors of the pancreas: A review of clinical, endoscopic, and pathologic features

Figure 1 Osteoclastic giant cell tumor of pancreas. A: Endoscopic-ultrasound guided fine needle aspirate specimen of a pancreatic mass. The smear slide contains a loose admixture of osteoclastic-giant cells admixed with oval to polygonal mononuclear cells (a-arrow). The individual giant cells have multiple bland appearing nuclei. The pleomorphic mononuclear cells are usually more numerous than the giant cells (b-arrow). (Romanowsky stain); B: A tissue section from the pancreatectomy specimen. The neoplasm contains a scattering of osteoclastic multinucleated giant cells with bland nuclei (arrows). These giant cells lie in a background of atypical mononuclear cells with pleomorphic nuclei. (HE stain).

Figure 2 Pleomorphic giant cell tumor of pancreas. A: Endoscopic-ultrasound guided fine needle aspirate of a pancreatic mass. These tumors are characterized by a mixture of markedly atypical mono and multinucleated giant cells. Both the mononuclear and multinucleated giant cells have similar appearing anaplastic nuclei (Papanicolaou stain); B: A tissue section from the pancreatectomy specimen. The neoplasm contains multinucleated giant cells (arrows) with hyperchromatic large, bizarre irregular tumor cell nuclei similar to the atypical mononuclear cells in the background (HE stain).

Figure 3 EUS image of a patient with an osteoclastic giant cell tumor of the pancreas. Note large size of mass and heterogeneous echotexture.