Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 16, 2022; 14(11): 684-693
Published online Nov 16, 2022. doi: 10.4253/wjge.v14.i11.684
Effectiveness and safety of endoscopic resection for duodenal gastrointestinal stromal tumors: A single center analysis
Zhen-Zhen Wang, Xiao-Dan Yan, Hai-Deng Yang, Xin-Li Mao, Yue Cai, Xin-Yu Fu, Shao-Wei Li
Zhen-Zhen Wang, Shao-Wei Li, Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Taizhou Hospital Affiliated to Wenzhou Medical University, Linhai 315000, Zhejiang Province, China
Zhen-Zhen Wang, Xiao-Dan Yan, Hai-Deng Yang, Xin-Li Mao, Yue Cai, Shao-Wei Li, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai 315000, Zhejiang Province, China
Zhen-Zhen Wang, Shao-Wei Li, Institute of Digestive Disease, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai 315000, Zhejiang Province, China
Xin-Yu Fu, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai 315000, Zhejiang Province, China
Author contributions: Wang ZZ, Mao XL, Yan XD, and Yang HD participated in the clinical treatment; Wang ZZ, Fu XY, and Cai Y wrote the original draft; Li SW undertook validation, writing, reviewing, and editing; All authors contributed to the article and approved the submitted version.
Supported by Medical Science and Technology Project of Zhejiang Province, No. 2021PY083; Program of Taizhou Science and Technology Grant, No. 22ywb09; Major Research Program of Taizhou Enze Medical Center Grant, No. 19EZZDA2; Open Project Program of Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, No. 21SZDSYS01 and 21SZDSYS09; Key Technology Research and Development Program of Zhejiang Province, No. 2019C03040; and Program of Taizhou Science and Technology Grant, No. 1901ky18.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University Institutional Review Board (Approval No. K20210611).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Wei Li, MD, Associate Professor, Research Assistant Professor, Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Taizhou Hospital Affiliated to Wenzhou Medical University, Ximen Street No. 150 Linhai 315000, Zhejiang Province, China. li_shaowei81@hotmail.com
Received: August 28, 2022
Peer-review started: August 28, 2022
First decision: September 12, 2022
Revised: September 28, 2022
Accepted: October 27, 2022
Article in press: October 27, 2022
Published online: November 16, 2022
ARTICLE HIGHLIGHTS
Research background

Currently, endoscopic resection of duodenal gastrointestinal stromal tumors (GISTs) is a challenging procedure with a high risk of complications.

Research motivation

Traditional surgical treatment methods for duodenal GISTs are traumatic and prone to serious complications. Endoscopic resection of duodenal GISTs is an alternative. However, there are few reports on endoscopic treatment for duodenal GISTs.

Research objectives

We aimed to evaluate the effectiveness and safety of endoscopic resection for duodenal GISTs.

Research methods

This was a retrospective study. We collected data of 11 consecutive patients with duodenal GISTs who were treated with endoscopic resection and analyzed the rate of complete resection, bleeding, perforation, postoperative infection, recurrence, and distant metastasis.

Research results

All lesions were completely resected, while three cases (27.3%) had suspected positive margins. No local recurrence or distant metastasis were detected during the follow-up period in any of the patients.

Research conclusions

Endoscopic resection for duodenal GISTs appears to be an effective and safe treatment by an experienced endoscopist.

Research perspectives

We need to expand the sample size to further confirm the effectiveness and safety of endoscopic resection of duodenal GISTs. In addition, the long-term outcome should be observed by extending the follow-up time.