Copyright
©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2018; 10(1): 82-87
Published online Jan 27, 2018. doi: 10.4254/wjh.v10.i1.82
Published online Jan 27, 2018. doi: 10.4254/wjh.v10.i1.82
Ratio of mean platelet volume to platelet count is a potential surrogate marker predicting liver cirrhosis
Hiroya Iida, Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki, Masanori Kon, Department of Surgery, Kansai Medical University, Osaka 573-1010, Japan
Author contributions: Iida H designed the research and performed the surgical interventions; Kaibori M performed the surgical interventions and contributed to the statistical assessment; Matsui K and Ishizaki M performed the surgical interventions; Kon M performed the surgical interventions and conferred on the final agreement for publication.
Institutional review board statement: The study was reviewed and approved by the Kansai Medical University Institutional Review Board.
Informed consent statement: Since this research was retrospective observation research using medical record information, the authors only gave the patient the opportunity to opt out. Therefore, there is no informed consent statement signed by the patients.
Conflict-of-interest statement: None of the authors have any conflicts of interest or financial disclosures.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hiroya Iida, MD, Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi Hirakata, Osaka 573-1010, Japan. hiroya0001@mac.com
Telephone: +81-72-8040101 Fax: +81-72-8042578
Received: March 26, 2017
Peer-review started: March 28, 2017
First decision: June 30, 2017
Revised: November 10, 2017
Accepted: December 4, 2017
Article in press: December 7, 2017
Published online: January 27, 2018
Peer-review started: March 28, 2017
First decision: June 30, 2017
Revised: November 10, 2017
Accepted: December 4, 2017
Article in press: December 7, 2017
Published online: January 27, 2018
Core Tip
Core tip: Although liver biopsy is considered the gold standard in the diagnosis of liver fibrosis and cirrhosis, liver biopsy is an invasive procedure, with attendant morbidity. Less invasive procedures are needed in the diagnosis of liver cirrhosis. Multivariate analysis showed that the mean platelet volume to platelet count ratio was independently predictive of liver cirrhosis. This ratio, which can be determined from a routine complete blood count, may be a simple surrogate marker predicting liver cirrhosis.