Retrospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2018; 10(1): 82-87
Published online Jan 27, 2018. doi: 10.4254/wjh.v10.i1.82
Ratio of mean platelet volume to platelet count is a potential surrogate marker predicting liver cirrhosis
Hiroya Iida, Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki, Masanori Kon
Hiroya Iida, Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki, Masanori Kon, Department of Surgery, Kansai Medical University, Osaka 573-1010, Japan
Author contributions: Iida H designed the research and performed the surgical interventions; Kaibori M performed the surgical interventions and contributed to the statistical assessment; Matsui K and Ishizaki M performed the surgical interventions; Kon M performed the surgical interventions and conferred on the final agreement for publication.
Institutional review board statement: The study was reviewed and approved by the Kansai Medical University Institutional Review Board.
Informed consent statement: Since this research was retrospective observation research using medical record information, the authors only gave the patient the opportunity to opt out. Therefore, there is no informed consent statement signed by the patients.
Conflict-of-interest statement: None of the authors have any conflicts of interest or financial disclosures.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Hiroya Iida, MD, Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi Hirakata, Osaka 573-1010, Japan.
Telephone: +81-72-8040101 Fax: +81-72-8042578
Received: March 26, 2017
Peer-review started: March 28, 2017
First decision: June 30, 2017
Revised: November 10, 2017
Accepted: December 4, 2017
Article in press: December 7, 2017
Published online: January 27, 2018

Several noninvasive methods for predicting cirrhosis have been reported, but liver biopsy is the only method for obtaining a definitive diagnosis. However, liver biopsy is invasive, and a noninvasive diagnostic method is desirable. Mean platelet volume (MPV), the size of platelets, can be determined from routine complete blood count data of blood samples. Generally, if bone marrow hematopoietic function decreases, MPV decreases. In contrast, if spleen function increases, new platelets are made rapidly and MPV increases. In recent years, the relationship between MPV and liver disease has attracted attention.

Research frontiers

There are reports that MPV correlates with liver function, and there are reports that MPV is related to the incidence of HCC. However, there is no report to evaluate the correlation between MPV/platelet count (PLT) and liver function, so we undertook this study.

Innovations and breakthroughs

The authors studied only patients who were diagnosed with cirrhosis histopathologically after liver resection. The MVP/PLT ratio could predict cirrhosis more sensitively than other general liver function tests.


The MPV/PLT ratio also correlated with the degree of hepatic fibrosis according to the Inuyama classification. The authors examined the relationship between prognosis after hepatic resection of hepatocellular carcinoma and the value of the MPV/PLT ration, but unfortunately no correlation was found.


MPV is the size of platelets and can be determined from routine complete blood count data of blood samples. Liver cirrhosis and fibrosis are related to MPV.