Collagen proportionate area correlates to hepatic venous pressure gradient in non-abstinent cirrhotic patients with alcoholic liver disease
Sophie Restellini, Nicolas Goossens, Francesco Negro, Laurent Spahr, Department of Medical Specialties, Division of Gastroenterology and Hepatology, Geneva University Hospitals and University of Geneva, Geneva 1205, Switzerland
Sophie Clément, Francesco Negro, Laura Rubbia-Brandt, Department of Genetic and Laboratory Medicine, Division of Clinical Pathology, Geneva University Hospitals and University of Geneva, Geneva 1205, Switzerland
Nicolas Lanthier, Laboratory of Gastroenterology and Hepatology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels 1200, Belgium
Author contributions: Restellini S and Goossens N contributed equally to this work; Restellini S, Goossens N, Lanthier N, and Spahr L contributed to acquisition of data; Restellini S, Goossens N, and Spahr L contributed to drafting of the article; all of the authors contributed to conception and design, analysis and interpretation of the data, critical revision of the article for important intellectual content, and final approval of the article.
Institutional review board statement: The study was reviewed and approved by the Geneva University Hospital Institutional Review Board.
Informed consent statement: Due to the retrospective, non-interventional nature of the study and in view of the irreversible anonymization of all clinical specimens and data, the requirement form informed consent was not required by the ethics committee of Geneva’s University Hospitals and University of Geneva as per local guidelines at time of the study submission.
Conflict-of-interest statement: The authors have no relevant conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Laurent Spahr, MD, Professor, Department of Medical Specialties, Division of Gastroenterology and Hepatology, Geneva University Hospitals and University of Geneva, 4, Rue Gabrielle Perret-Gentil, Geneva 1205, Switzerland. firstname.lastname@example.org
Telephone: +41-223-729340 Fax: +41-223-729366
Received: November 21, 2017
Peer-review started: November 22, 2017
First decision: December 7, 2017
Revised: December 15, 2017
Accepted: January 9, 2018
Article in press: January 9, 2018
Published online: January 27, 2018